Evidence map›Paper›PMID 42482199›Full record

ArticleBMC microbiology2026

Ec_Ou_ZC1, a new Tunavirus, reveals Cor superinfection exclusion and differential Avs susceptibility across Drexlerviridae subfamilies.

Quanrui Zhang, Yingying Liu, Jiaoxia Qin, Jixia Wei, Fan Yang, Tao Zhang, Qunxin She, Chen Zhang, Min Wu

Abstract read
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In one paragraph

Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Quanrui Zhang *School of Biological Sciences and Technology, Chengdu Medical College, Chengdu, China.
Yingying Liu *Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China. yingying03.liu@gmail.com.
Jiaoxia QinWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China.
Jixia WeiWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China.
Fan YangWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China.
Tao ZhangSchool of Biological Sciences and Technology, Chengdu Medical College, Chengdu, China.
Qunxin SheCRISPR and Archaea Biology Research Center, State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao, China.
Chen ZhangWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China. chen03.zhang@gmail.com.
Min WuWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, China. miw100@hotmail.com.

Funding

Joint Program of State Key Laboratory of Microbial Technology ,Shandong University No.M2025-03National Key Research Project of MOST 2023YFA0915000National Natural Science Foundation of China Nos.82470005
6 · The paper itself

Abstract

The global rise of antibiotic resistance has rekindled interest in bacteriophages (phages) as alternative therapeutics. Here, we isolated and characterized a novel Escherichia coli phage, Ec_Ou_ZC1, from the family Drexlerviridae, genus Tunavirus, sharing 94.72% genomic identity with Escherichia phage phiD2-2. Ec_Ou_ZC1 encodes an orphan methyltransferase and a Cor superinfection exclusion (SIE) protein. Heterologous expression of Cor blocked all tested FhuA-dependent Drexlerviridae phages (Ec_Ou_ZC1, T1, Bas03, Bas12, Bas13) but not T4 or T7, confirming family-specific SIE through FhuA receptor inactivation. Plaque assays against four antiviral STAND (Avs) systems revealed differential susceptibility within Drexlerviridae: Bas03 (Braunvirinae) was sensitive to SeAvs3, while Ec_Ou_ZC1, Bas05, Bas12, Bas13, and T1 (Tempevirinae and Tunavirinae) resisted all four systems, suggesting that Avs resistance depends on specific genomic features. Species-level phylogenetic analyses using concatenated single-copy orthologs robustly resolved evolutionary relationships within Tunavirus, separating Escherichia- and Shigella-infecting phages and providing a framework for predicting host range of new isolates.

Indexed as

ColiphagesEscherichia coliGenome, ViralHost SpecificityMethyltransferasesPhylogenyViral ProteinsMethyltransferasesViral ProteinsAntiphage immunityComparative genomicsPhage therapyPhylogenetic constructionPolyvalenceSuperinfection exclusionTunavirus

Identifiers

PMID42482199

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.