ArticleJournal of medical case reports2026
Moist wound healing theory in neonatal aplasia cutis congenita: a case report.
Article in Journal of medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
key messageThis clinical case demonstrates complete epithelialization of a neonatal scalp defect through staged application of moist wound dressings (silver, foam, hydrogel) that controlled inflammation, managed exudate, and promoted granulation, achieving rapid healing with minimal scarring.
backgroundAplasia cutis congenita (ACC) is a rare developmental disorder with an estimated incidence of 0.5-1 per 10,000 live births. Currently, there is no standardized treatment protocol, especially for severe cases with potential skull exposure. The moist wound healing theory, which promotes cell migration and tissue regeneration by simulating physiological conditions, has recently demonstrated significant advantages in chronic wound management. This study presents a multidisciplinary approach to neonatal ACC management based on moist wound healing principles, providing novel insights for clinical practice. CASE PRESENTATION: A male newborn of Han Chinese ethnicity, delivered at 38⁺
conclusionsThis case demonstrates that a phased, multidisciplinary management strategy based on moist wound healing theory can effectively promote healing in neonatal ACC, avoiding the infection risks and secondary trauma associated with traditional dry eschar formation. The protocol significantly improved healing quality and the patient's treatment experience, highlighting its considerable potential for broad clinical adoption.
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