Evidence map›Paper›PMID 42481895›Full record

ArticleJournal of computer-aided molecular design2026

Design, synthesis, biological evaluation, and in silico analysis of novel coumarin carboxamides as acetylcholinesterase and butyrylcholinesterase inhibitors and anticancer agents.

Kadircan Ural, Bulent Ozpolat, Ferah Comert Onder

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of computer-aided molecular design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Design, Synthesis,ACS omega · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kadircan UralDepartment of Medical System Biology, School of Graduate Studies, Çanakkale Onsekiz Mart University, 17020, Çanakkale, Turkey.ORCID 0009-0002-1287-1308
Bulent OzpolatDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA.ORCID 0000-0001-8602-7463
Ferah Comert OnderDepartment of Medical Biology, Faculty of Medicine, Çanakkale Onsekiz Mart University, 17020, Çanakkale, Turkey. ferahcomertonder@comu.edu.tr.ORCID 0000-0002-4037-1979

Funding

Çanakkale Onsekiz Mart University the Research Coordination Unit TYL-2024-4744
6 · The paper itself

Abstract

In this study, coumarin-3-carboxamide derivatives were designed and evaluated through a comprehensive in silico and in vitro combined approaches to identify cholinesterase inhibitors. Molecular docking, molecular dynamics (MD) simulations, and MM/GBSA analyses revealed strong binding affinities and stable interactions within key catalytic regions of AChE and BChE, with AChE-CM4 (ΔG

Indexed as

AcetylcholinesteraseAntineoplastic AgentsButyrylcholinesteraseCholinesterase InhibitorsCoumarinsCell Line, TumorDrug DesignHumansMolecular Docking SimulationMolecular Dynamics SimulationStructure-Activity RelationshipAcetylcholinesteraseAntineoplastic AgentsButyrylcholinesteraseCholinesterase InhibitorscoumarinCoumarinsAChEBChECholinesterase inhibitorsCoumarinIn silicoIn vitroMD simulationMM/GBSA

Identifiers

PMID42481895

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.