Evidence map›Paper›PMID 42481771›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2026

Minimally invasive extracavitary approach for selected ventral intradural extramedullary thoracic lesions: quantitative anatomical analysis and technical feasibility.

Filippo Gagliardi, Lina Raffaella Barzaghi, Pierfrancesco De Domenico, Silvia Snider, Francesca Roncelli, Pietro Mortini

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Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Filippo GagliardiDepartment of Neurosurgery and Gamma Knife Radiosurgery, IRCCS Ospedale San Raffaele, Milan, Italy.
Lina Raffaella BarzaghiDepartment of Neurosurgery and Gamma Knife Radiosurgery, IRCCS Ospedale San Raffaele, Milan, Italy.
Pierfrancesco De DomenicoDepartment of Neurosurgery and Gamma Knife Radiosurgery, IRCCS Ospedale San Raffaele, Milan, Italy. dedomenico.pierfrancesco@hsr.it.ORCID https://orcid.org/0000-0003-3330-162X
Silvia SniderDepartment of Neurosurgery and Gamma Knife Radiosurgery, IRCCS Ospedale San Raffaele, Milan, Italy.
Francesca RoncelliDepartment of Neurosurgery and Gamma Knife Radiosurgery, IRCCS Ospedale San Raffaele, Milan, Italy.
Pietro MortiniDepartment of Neurosurgery and Gamma Knife Radiosurgery, IRCCS Ospedale San Raffaele, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe and evaluate the application of the minimally invasive extracavitary approach (miECA) for selected ventral intradural extramedullary thoracic lesions through a combined quantitative anatomical study and proof-of-concept clinical application.

backgroundSurgical treatment of ventral intradural extramedullary lesions of the thoracic spine remains technically demanding because the spinal cord lies directly within the operative corridor. Although conventional posterior approaches are effective in most cases, selected lesions may require substantial spinal cord mobilization to achieve adequate exposure, potentially increasing the risk of neurological morbidity.

methodsA quantitative anthropometric neuroimaging study was performed on a reference population to characterize the geometry of the miECA corridor to the ventral intradural (premedullary) space. Working distance (WD), maneuverability arc (MAC), and surgical angle of incidence (SAI) were measured using a previously validated operability score methodology. These data were integrated with a proof-of-concept clinical application to assess technical feasibility and safety. An illustrative case is presented.

resultsThe miECA provided a muscle-sparing, stability-preserving surgical corridor with favorable geometry, characterized by a median SAI of 55.0° (interquartile range [IQR] 50.0-60.0), a median MAC of 45° (IQR 40-65) and a median WD of 8.0 cm (IQR 6.0-9.0). This configuration enabled direct access to the ventral intradural premedullary space while minimizing the need for spinal cord mobilization. Endoscopic assistance further enhanced the visualization of the ventral intradural compartment. In the illustrative case, complete tumor resection was achieved without procedure-related neurological deterioration.

conclusionsThe miECA may represent a useful adjunct for carefully selected ventral intradural extramedullary thoracic lesions in which conventional posterior routes are expected to require substantial spinal cord manipulation. The present study establishes anatomical feasibility and provides preliminary technical guidance for future clinical applications.

Indexed as

Intradural extramedullary tumorsMinimally invasive extracavitary approachSpinal cord preservationThoracic spineVentral intradural space

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.