Evidence map›Paper›PMID 42481742›Full record

Reviewnpj drug discovery2026

Targeting druggable kinases in neuropathic pain.

Harrison Benson, Komalpreet Kaur, Mahmoud Salama Ahmed

Abstract readReview
In one paragraph

Review in npj drug discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Harrison BensonDepartment of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Science Center, Amarillo, TX, USA.
Komalpreet KaurDepartment of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Science Center, Amarillo, TX, USA.
Mahmoud Salama AhmedDepartment of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Science Center, Amarillo, TX, USA. mahmoudsalama.ahmed@ttuhsc.edu.

Funding

Identification of novel lead EphB1/2 tyrosine kinase inhibitors targeting peripheral neuropathic painR01NS136485 · NINDS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI Mahmoud Salama Ahmed · 2025 to 2026
$776k
NINDS NIH HHS 1R01NS136485-01A1NINDS NIH HHS R01 NS136485
6 · The paper itself

Abstract

Despite the prevalence of neuropathic pain and the opioid crisis, there has been little progress in the development of non-opioid alternative therapies. Protein kinases orchestrate multiple key pathophysiological events in the progression of pain signaling pathways. This review highlights druggable kinases and the associated scaffolds as well as molecular modalities to reverse mechanical allodynia and thermal hyperalgesia in neuropathy models whether preclinically or clinically.

Identifiers

PMID42481742
PMCPMC13388951

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.