Evidence map›Paper›PMID 42481722›Full record

ArticleCommunications biology2026

Synchrony between brain age and internalising and externalising symptoms across adolescence.

Dani Beck, Chloe Carrick, Eira R Aksnes, Niamh MacSweeney, Lars T Westlye, Delia Fuhrmann, Christian K Tamnes

Abstract read
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In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. The Brain Age Gap as a Predictor of Alcohol Initiation in Adolescence.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Dani BeckPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway. dani.beck@psykologi.uio.no.ORCID http://orcid.org/0000-0002-0974-9304
Chloe CarrickDepartment of Psychology, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0009-0002-6219-4341
Eira R AksnesPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Niamh MacSweeneyPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
Lars T WestlyeDepartment of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0001-8644-956X
Delia FuhrmannDepartment of Psychology, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Christian K TamnesPROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-9191-6764

Funding

Ministry of Health and Care Services | Helse Sør-Øst RHF (Southern and Eastern Norway Regional Health Authority) 2021070Ministry of Health and Care Services | Helse Sør-Øst RHF (Southern and Eastern Norway Regional Health Authority) 2023012Ministry of Health and Care Services | Helse Sør-Øst RHF (Southern and Eastern Norway Regional Health Authority) 500189Norges Forskningsråd (Research Council of Norway) 323951
6 · The paper itself

Abstract

Adolescence is a period of rapid neurobiological and behavioural change, yet how brain maturation deviations relate to psychopathology remains unclear. Here, we show, using data from the Adolescent Brain Cognitive Development Study, that deviations in brain age are coupled with internalising and externalising symptom development across adolescence. Combining multimodal brain age prediction across four waves (ages ~8.3-17.5) with bivariate latent growth curve models of ten symptom waves, we found coordinated nonlinear development between brain maturation and symptoms: adolescents whose brains increasingly diverged from age-expected maturation showed increasing symptoms. Effects were most consistent for internalising symptoms in females (r = 0.15-0.23) and broader for externalising symptoms in both sexes (r = 0.15-0.32); intercept-level associations were weaker (r = 0.08-0.09). Sex differences were not robust after correction. Vulnerability to adolescent psychopathology appears more closely linked to changes in brain maturational tempo than to fixed differences in brain age.

Identifiers

PMID42481722

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.