Evidence map›Paper›PMID 42481708›Full record

ArticleNature nanotechnology2026

Computationally guided design of bioactive nanostructures for targeted clearance of amyloid-β aggregates in Alzheimer's disease.

Tianyi Qi, Jingxuan Fu, Yajie Wang, Ming Zhao, Zhaoxu Zhang, Weicheng Peng, Qiqi Liu, Minghao Liu, Shibai Li, Qiannan Duan and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature nanotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tianyi Qi *Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin, China.ORCID http://orcid.org/0009-0007-8786-1880
Jingxuan Fu *Key Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, China.
Yajie WangKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin, China.ORCID http://orcid.org/0000-0001-5116-9824
Ming ZhaoKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin, China.
Zhaoxu ZhangKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, China.
Weicheng PengKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin, China.
Qiqi LiuKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin, China.
Minghao LiuKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin, China.
Shibai LiKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin, China.
Qiannan DuanKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin, China.
Chunyu WangKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin, China.
Jie ZhuangSchool of Medicine, Nankai University, Tianjin, China.ORCID http://orcid.org/0009-0006-4481-0672
Xiyun YanCAS Engineering Laboratory for Nanozymes, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-7290-352X
Yijin LiuKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin, China. yvliu@nankai.edu.cn.ORCID http://orcid.org/0000-0002-3643-8683
Hui WangKey Laboratory of Molecular Biophysics, Hebei Province, Institute of Biophysics, School of Health Sciences and Biomedical Engineering, School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, China. huiwang@hebut.edu.cn.ORCID http://orcid.org/0000-0002-5756-3774
Xinglu HuangKey Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin, China. huangxinglu@nankai.edu.cn.ORCID http://orcid.org/0000-0002-9378-7425

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32271448National Natural Science Foundation of China (National Science Foundation of China) 32425032National Natural Science Foundation of China (National Science Foundation of China) 82471465National Natural Science Foundation of China (National Science Foundation of China) 82472134
6 · The paper itself

Abstract

Targeted clearance of pre-existing amyloid-β (Aβ) aggregation remains a central challenge in Alzheimer's disease (AD) therapy. Here we report a computationally guided protein-gold hybrid nanostructure,

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesMetal NanoparticlesNanostructuresProtein Aggregation, PathologicalAnimalsFerritinsGoldHumansMiceMice, TransgenicProtein AggregatesAmyloid beta-PeptidesFerritinsGoldProtein Aggregates

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.