Evidence map›Paper›PMID 42481501›Full record

ArticleNature communications2026

Behaviourally driven closed-loop beta-tACS enhances beta activity and motor behaviour.

Min Wu, Zeyu Xu, Melanie K Fleming, Nicholas Shackle, Lara Biller, Faye Tabone, Pei-Ling Wong, Caroline Nettekoven, Andrew Sharott, Catharina Zich and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Min Wu *Oxford Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. min.wu@ndcn.ox.ac.uk.ORCID http://orcid.org/0009-0005-7952-5997
Zeyu Xu *Oxford Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Melanie K FlemingOxford Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-2232-9598
Nicholas ShackleMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK.ORCID http://orcid.org/0009-0008-7914-9540
Lara BillerOxford Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Faye TaboneOxford Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0009-0008-0119-1773
Pei-Ling WongDepartment of Physical Therapy and Assistive Technology, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.ORCID http://orcid.org/0000-0001-5710-9881
Caroline NettekovenDepartment of Experimental Psychology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-5427-2907
Andrew SharottMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-1594-3349
Catharina ZichOxford Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK. catharina.zich@ndcn.ox.ac.uk.ORCID http://orcid.org/0000-0002-0705-9297
Charlotte J StaggOxford Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-5542-5036

Funding

Wellcome TrustWellcome Trust (Wellcome) 222446/Z/21/ZWellcome Trust (Wellcome) 224430/Z/21/ZWellcome Trust (Wellcome) 306553/Z/23/ZZonMw (Netherlands Organisation for Health Research and Development) Rubicon-04520232310005
6 · The paper itself

Abstract

Movement-related beta event-related synchronization (ERS) has been linked to motor control and learning, showing potential as a therapeutic target for those with movement deficits, such as stroke survivors. However, whether directly modulating beta ERS can causally influence motor performance remains unclear, largely due to the lack of methods designed to specifically target this neural activity. To address this gap, we developed a behaviourally-driven, closed-loop transcranial alternating current stimulation (tACS) approach to target movement-related beta ERS during a visuomotor adaptation task. We found that the behaviourally-driven, closed-loop beta-tACS specifically enhances beta ERS without affecting beta event-related desynchronization (ERD). Critically, this targeted enhancement significantly improves retention of motor adaptation. These findings support a functional role of beta ERS in motor behaviour and suggest that behaviourally-driven beta-tACS may provide a promising approach to further test the mechanistic links between beta ERS and behavioural outcomes in clinical populations.

Indexed as

Beta RhythmMotor ActivityTranscranial Direct Current StimulationAdaptation, PhysiologicalFemaleHumansMotor CortexPsychomotor Performance

Identifiers

PMID42481501
PMCPMC13503910

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.