Evidence map›Paper›PMID 42481499›Full record

ArticleNature communications2026

Symmetry-driven gating of TRPM8 by PIP

Sun-Hong Kim, Chansik Hong, Hyunwoo Park, Youngchang Ju, Youngsoo Hwang, Jinhyeong Kim, Sangho Ji, Wookyung Yu, Insuk So, Hyung Ho Lee

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Chill factor.Nature structural & molecular biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sun-Hong Kim *Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.ORCID 0000-0001-5195-1613
Chansik Hong *Department of Physiology, College of Medicine, Chosun University, Gwangju, Republic of Korea.ORCID 0000-0001-9684-4651
Hyunwoo Park *Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.ORCID 0009-0009-2055-7854
Youngchang JuDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of Korea.ORCID 0009-0005-7709-6949
Youngsoo HwangDepartment of Chemistry, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.
Jinhyeong KimDepartment of Physiology and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Sangho JiDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of Korea.
Wookyung YuDepartment of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu, Republic of Korea.ORCID 0000-0001-9835-930X
Insuk SoDepartment of Physiology and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea. insuk@snu.ac.kr.ORCID 0000-0003-2294-2050
Hyung Ho LeeDepartment of Chemistry, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea. hyungholee@snu.ac.kr.ORCID 0000-0003-1168-2484

Funding

National Research Foundation of Korea (NRF) RS-2025-00514715
6 · The paper itself

Abstract

TRPM8, a cold-activated ion channel, enables mammals to sense cooling agents such as menthol. While PIP

Indexed as

Ion Channel GatingMentholPhosphatidylinositol 4,5-DiphosphateTRPM Cation ChannelsAnimalsCalciumCryoelectron MicroscopyHEK293 CellsMiceModels, MolecularProtein BindingProtein ConformationPyrimidinonesCalciumicilinMentholPhosphatidylinositol 4,5-DiphosphatePyrimidinonesTRPM8 protein, mouseTRPM Cation Channels

Identifiers

PMID42481499
PMCPMC13400742

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.