Evidence map›Paper›PMID 42481472›Full record

ArticleNature communications2026

Fluorofenidone ameliorates pressure overload-induced heart failure by stabilizing SERCA2a in male mice.

Quan Liu, Huayang Li, Jiantao Chen, Qiushi Ren, Tongxin Chu, Li Luo, Zeyu Li, Suiqing Huang, Liqun Shang, Adilai Maihemuti and 7 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Quan Liu *Department of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.ORCID http://orcid.org/0000-0003-2585-0960
Huayang Li *Department of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Jiantao Chen *Department of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Qiushi Ren *Department of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Tongxin Chu *Department of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Li Luo *Department of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.ORCID http://orcid.org/0000-0001-7809-6821
Zeyu LiDepartment of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Suiqing HuangDepartment of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Liqun ShangDepartment of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Adilai MaihemutiDepartment of Operating Room, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhuoming ZhouDepartment of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Zhilin MiaoDepartment of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Kaizheng LiuDepartment of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Jinyu PanDepartment of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Kangni FengDepartment of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. fengkni@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-9722-9375
Mengya LiangDepartment of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. liangmya@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-5005-327X
Zhongkai WuDepartment of Cardiac Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. wuzhk@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0003-1184-1182

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82370271National Natural Science Foundation of China (National Science Foundation of China) 82404613
6 · The paper itself

Abstract

Reduced expression and activity of cardiac sarco/endoplasmic reticulum Ca

Indexed as

Heart FailurePyridonesSarcoplasmic Reticulum Calcium-Transporting ATPasesAnimalsHumansMaleMiceMice, Inbred C57BLMyocytes, CardiacUbiquitinationUbiquitin-Protein LigasesAtp2a2 protein, mousePyridonesSarcoplasmic Reticulum Calcium-Transporting ATPasesUbiquitin-Protein Ligases

Identifiers

PMID42481472
PMCPMC13500547

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.