Evidence map›Paper›PMID 42481459›Full record

ArticleNature communications2026

Hardware acceleration of simulated annealing for constraint satisfaction problems.

Andrew Pannone, Rishikesh T Nair, Pranav Krishnan, Fabio Carletti, Harikrishnan Ravichandran, Priyatam Gundapuneni, Arav Dutta, Subir Ghosh, Chen Chen, Joan M Redwing and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Andrew Pannone *Engineering Science and Mechanics, Penn State University, University Park, PA, USA.ORCID http://orcid.org/0000-0001-8446-9946
Rishikesh T Nair *Engineering Science and Mechanics, Penn State University, University Park, PA, USA.
Pranav KrishnanEngineering Science and Mechanics, Penn State University, University Park, PA, USA.
Fabio CarlettiElettronica, Informazione e Bioingegneria, Politecnico di Milano, Milan, Italy.
Harikrishnan RavichandranEngineering Science and Mechanics, Penn State University, University Park, PA, USA.ORCID http://orcid.org/0009-0002-2230-370X
Priyatam GundapuneniMechanical Engineering, Penn State University, University Park, PA, USA.
Arav DuttaEngineering Science and Mechanics, Penn State University, University Park, PA, USA.
Subir GhoshEngineering Science and Mechanics, Penn State University, University Park, PA, USA.ORCID http://orcid.org/0000-0002-0883-4478
Chen Chen2D Crystal Consortium Materials Innovation Platform, Penn State University, University Park, PA, USA.ORCID http://orcid.org/0000-0001-9027-7107
Joan M Redwing2D Crystal Consortium Materials Innovation Platform, Penn State University, University Park, PA, USA.ORCID http://orcid.org/0000-0002-7906-452X
Saptarshi DasEngineering Science and Mechanics, Penn State University, University Park, PA, USA. sud70@psu.edu.ORCID http://orcid.org/0000-0002-0188-945X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Simulated annealing (SA), a metaheuristic algorithm inspired by physical annealing processes, attempts to solve combinatorial optimization problems by performing a stochastic search that iteratively explores the solution space. Probabilistic solution evaluation allows the algorithm to escape local minima and progressively converge toward a global optimum, even within complex solution landscapes. In this work, we present the hardware acceleration of SA for spatial optimization within constrained environments, specifically targeting drone placement that maximizes area coverage while avoiding no-fly zones. Stochasticity is introduced through a true random number generator (TRNG) based on two-dimensional (2D) materials. The system energy is evaluated using a 2D logic circuit and the acceptance of candidate solutions is governed by a programmable 2D circuit with tunable threshold behavior. For a representative drone placement task, our hardware-based annealing accelerator circuit modules consume 43 nJ of energy per iteration and achieve an 1800-fold search acceleration relative to brute-force exploration of the solution space. This work also underscores the potential of 2D-material-enabled stochastic and programmable hardware for real-time constrained optimization.

Identifiers

PMID42481459
PMCPMC13503799

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.