ArticleCell death discovery2026
PIN1 enhances SUMOylation of YAP1 and inhibits ferroptosis via autophagy-dependent degradation of ACSL4 in cervical cancer.
Article in Cell death discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Itaconate metabolism in regulated cell death.Molecular and cellular biochemistry · 2026Review
- Metabolic cell death: ferroptosis, cuproptosis, and disulfidptosis as a unified framework for targeting metabolic vulnerabilities in disease.Apoptosis : an international journal on programmed cell death · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cervical cancer (CC) is a prevalent malignancy threatening women's health. Due to its complex pathogenesis and tumor heterogeneity, it is urgent to thoroughly investigate its pathological mechanisms. Based on the TCGA database, the expression and survival analysis of PIN1 and YAP1 were assessed in CC. To verify their roles in regulating CC, stable knockdown and overexpression cell lines were constructed in CC cell lines. In vivo and in vitro experiments were conducted to verify that PIN1 regulates YAP1's SUMOylation levels and induces ACSL4's autophagic degradation. This research shows that PIN1 binds to YAP1, promoting its SUMOylation and causing autophagy-mediated degradation of ACSL4, enabling cervical cancer cells to resist ferroptosis. In vivo xenograft models confirm these findings. This study identifies PIN1 as a key redox-balance node and presents it as a potential therapeutic target for CC ferroptosis. Inhibiting PIN1 and YAP1 can inhibit tumor progression, offering a promising approach for treating aggressive CC.
Identifiers
42481442What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.