ArticleChemMedChem2026
Novel Benzofuranyl Chalcones With Antileishmanial Activity: Synthesis, Structure-Activity Relationships, and Computational Target Hypothesis Studies.
Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Leishmaniasis remains a major unmet medical need, and the development of new selective antileishmanial chemotypes is still urgently required. Herein, we report the design, synthesis, and biological evaluation of two series of benzofuranyl chalcones as antileishmanial agents against L. mexicana. Primary screening at 5 µg/mL identified 25 compounds that inhibited parasite metabolism by more than 50%, supporting the benzofuranyl chalcone framework as a productive antileishmanial scaffold. Dose-response studies revealed several low-micromolar leads, with compound 14l as the most potent analog (IC
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