Evidence map›Paper›PMID 42481422›Full record

Observational studyRMD open2026

Oral microbiome dysbiosis and oral-gut microbial network disruption in hand osteoarthritis: data from the Xiangya Osteoarthritis Study.

Jiatian Li, Yadan Xiao, Tuo Yang, David J Hunter, Weiya Zhang, Michael Doherty, Yuqing Zhang, Zidan Yang, Yilun Wang, Dongxing Xie and 7 more

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in RMD open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04033757 (A Population-based Cohort of Osteoarthritis), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04033757 active not recruitingnot on this map

A Population-based Cohort of Osteoarthritis: the Xiangya Osteoarthritis Study

Typeobservational_patient_registrySponsorXiangya Hospital of Central South UniversityRan2015 to 2031Enrolled4,080ConditionsOsteoarthritis
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jiatian Li *Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0000-0002-1519-0615
Yadan Xiao *Department of Epidemiology and Health Statistics, Xiangya School of Public Health, Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0009-0000-9521-0809
Tuo Yang *Health Management Center, Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0000-0003-0738-4812
David J HunterRheumatology Department, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-3197-752X
Weiya ZhangAcademic Rheumatology, School of Medicine, University of Nottingham, Nottingham, UK.
Michael DohertyAcademic Rheumatology, School of Medicine, University of Nottingham, Nottingham, UK.
Yuqing ZhangDivision of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Zidan YangHunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yilun WangDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0000-0002-9468-4110
Dongxing XieDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Changjun LiHunan Key Laboratory of Joint Degeneration and Injury, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Kai ZhaoDepartment of Hematology and Critical Care Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China.
Wei LiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0000-0002-8891-9067
Zeqin WenDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chao ZengDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China weij1988@csu.edu.cn zengchao@csu.edu.cn lei_guanghua@csu.edu.cn.
Guanghua LeiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China weij1988@csu.edu.cn zengchao@csu.edu.cn lei_guanghua@csu.edu.cn.ORCID http://orcid.org/0000-0003-2987-138X
Jie WeiDepartment of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China weij1988@csu.edu.cn zengchao@csu.edu.cn lei_guanghua@csu.edu.cn.ORCID http://orcid.org/0000-0003-3510-8241

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe oral microbiome plays a critical role in modulating systemic inflammation, partly through its interactions with the gut microbiome. Although gut microbiome dysbiosis has been implicated in symptomatic hand osteoarthritis (SHOA), the role of oral microbiome dysbiosis in SHOA and its relationship with gut microbiome dysbiosis remain unclear. Elucidating these associations could provide novel insights into SHOA pathogenesis.

methodsParticipants were recruited from the Xiangya Osteoarthritis (XO) Study, an ongoing community-based observational study. Saliva samples were analysed using 16S ribosomal RNA gene sequencing. Oral microbial richness, composition and relative abundance of specific taxa were compared between SHOA participants and controls without SHOA. Correlations within the oral-gut microbiome network were also assessed and compared between groups.

resultsCompared with controls (n=712), participants with SHOA (n=52) exhibited significantly lower oral microbial richness (p=0.007) and altered composition (p=0.007). The relative abundance of the genus

conclusionOral microbiome dysbiosis and disruption of the oral-gut microbiome network are associated with prevalent SHOA. These findings suggest a potential role of the oral-gut microbiome axis in SHOA pathogenesis. Larger studies are needed to confirm these associations. TRIAL REGISTRATION NUMBER: NCT04033757.

Indexed as

DysbiosisGastrointestinal MicrobiomeMicrobiotaMouthOsteoarthritisAgedBacteriaCase-Control StudiesFemaleHumansMaleMiddle AgedRNA, Ribosomal, 16SRNA, Ribosomal, 16SBiomarkersEpidemiologyOsteoarthritisRisk Factors

Identifiers

PMID42481422
PMCPMC13410909

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.