Evidence map›Paper›PMID 42481419›Full record

ArticleGenes & development2026

Isoform-paralog specificity and tissue-dependent vulnerabilities in neurological disorders.

Karina Hernandez-Quijada, Kenneth Y Kwan

Abstract readComment
In one paragraph

Article in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Karina Hernandez-QuijadaMichigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, Michigan 48109, USA.
Kenneth Y KwanMichigan Neuroscience Institute (MNI), University of Michigan, Ann Arbor, Michigan 48109, USA; kykwan@umich.edu.

Funding

Distinct roles of chromatin regulation in transcriptome and genome maintenance in corticogenesisR01MH126287 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kenneth Yu-Chung Kwan · 2022 to 2026
$2.8M
Subplate-dependent mechanisms of cortical circuit assemblyR01NS125313 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kenneth Yu-Chung Kwan · 2022 to 2026
$2.4M
NIMH NIH HHS R01 MH126287NINDS NIH HHS R01 NS125313
6 · The paper itself

Abstract

A long-standing observation in studies of neurological disorders is that broadly expressed disease genes can cause dysfunctions that are limited to certain brain regions or cell types. In this issue of

Indexed as

Ataxin-1Nervous System DiseasesAnimalsHumansOrgan SpecificityProtein IsoformsRepressor ProteinsAtaxin-1CIC protein, humanProtein IsoformsRepressor ProteinsATXN1ATXN1LCapicuaCICisoformneurodegenerationneurodevelopmentparalogprotein complex

Identifiers

PMID42481419
PMCPMC13431150

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.