The Hidden Burden: Endocrinopathies in Adolescents after Hematopoietic Stem Cell Transplantation.

Harinder Dosanjh Raipuria, Catherine M Gordon

Abstract readReview

In one paragraph

Review in Advances in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Harinder Dosanjh RaipuriaPediatric Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA; Section on Adolescent Bone Health & Body Composition, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA. Electronic address: harinder.raipuria@nih.gov.

Catherine M GordonPediatric Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA; Section on Adolescent Bone Health & Body Composition, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Funding

Adolescent Bone Density & Body Composition SectionZIAHD009023 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI GORDON, CATHERINE · 2024 to 2025

$1.2M

Intramural NIH HHS Z99 HD999999Intramural NIH HHS ZIA HD009023

6 · The paper itself

Abstract

Adolescents with malignant and nonmalignant diagnoses can require hematopoietic stem cell transplantation (HSCT), with the volume increasing 5% to 10% per annum in the United States. HSCT is an established therapy for malignancies, hemoglobinopathies, bone marrow failure, inborn errors of metabolism, and immunodeficiency. Gonadotoxic-conditioning regimens, immunosuppressive agents, and glucocorticoids are essential therapies required for a successful transplant course. Secondary endocrine sequelae can occur, however, including iatrogenic adrenal insufficiency, reduced bone mineral density, medication-induced hyperglycemia, and premature ovarian insufficiency. With broader indications for HSCT use, at-risk endocrinopathies in the post-transplant period require prompt recognition and assessment, monitoring, and medical management.

Indexed as

Endocrine System DiseasesHematopoietic Stem Cell TransplantationAdolescentFemaleGlucocorticoidsHumansImmunosuppressive AgentsPrimary Ovarian InsufficiencyGlucocorticoidsImmunosuppressive AgentsAdrenal insufficiencyBone mineral densityGlucocorticoidsGonadotoxic therapiesHematopoietic stem cell transplantationHyperglycemiaImmunosuppressionPremature ovarian insufficiency

Identifiers

PMID42481090

DOI10.1016/j.yapd.2025.12.011

PMCPMC13403924

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.