Evidence map›Paper›PMID 42481084›Full record

ReviewAdvances in pediatrics2026

The Congenital Syphilis Surge: Clinician Lessons to Turn the Rising Tide.

Neema Pithia, Karin Nielsen-Saines, Kristina Adachi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Neema PithiaDepartment of Pediatrics, Division of Infectious Diseases, UCLA, Los Angeles, CA, USA; Kaiser Department of Neonatology.
Karin Nielsen-SainesDepartment of Pediatrics, Division of Infectious Diseases, UCLA, Los Angeles, CA, USA.
Kristina AdachiDepartment of Pediatrics, Division of Infectious Diseases, UCLA, Los Angeles, CA, USA. Electronic address: kadachi@mednet.ucla.edu.

Funding

Evaluation of antimicrobial prophylaxis to prevent syphilis in pregnancy in patients at risk in Rio de Janeiro, BrazilR01AI187414 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Esau Custodio Joao, Karin Nielsen · 2025 to 2026
$1.2M
NIAID NIH HHS R01 AI187414
6 · The paper itself

Abstract

Congenital syphilis (CS) refers to in utero syphilis infection of the developing fetus. CS can be prevented by timely syphilis screening and treatment in pregnancy. CS has become a US public health crisis in the past decade. In response, public health experts and professional societies now recommend increasing the frequency of syphilis testing in pregnancy. All infants born to women with syphilis in pregnancy require careful evaluation and nontreponemal titers to determine CS diagnosis, evaluation, and management. These infants should also receive close follow-up and repeat nontreponemal titers. Most infants diagnosed and treated early for CS have a favorable prognosis.

Indexed as

Infectious Disease Transmission, VerticalPregnancy Complications, InfectiousSyphilis, CongenitalFemaleHumansInfant, NewbornPregnancySyphilisSyphilis SerodiagnosisUnited StatesCongenital syphilisIn utero syphilisNontreponemal and treponemal tests

Identifiers

PMID42481084
PMCPMC13541238

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.