ArticleArquivos de neuro-psiquiatria2026
Distinct thalamic volumetric profiles in cervical and upper limb dystonia.
Article in Arquivos de neuro-psiquiatria, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Dystonia is a large-scale motor network disorder involving the basal ganglia, cerebellum, and thalamus. Objective: This study investigated the volumetric characteristics of thalamic subnuclei in patients with isolated cervical (CD) and upper limb (ULD) dystonias, and their relationship with disease severity. Methods: We analyzed high-resolution T1-weighted MR-images from the OpenNeuro database. The sample included 37 healthy controls, 25 CD, and 29 ULD patients. Thalamic nuclei were automatically segmented using the DeepThalamus pipeline. Group differences were analyzed using analysis of covariance (ANCOVA), controlling for age, sex, and total intracranial volume (TIV). Relationships between disease severity and volumetry were assessed using Spearman's correlation. Results: A volumetric reduction trend was observed in the CD group compared with controls, particularly in the left lateral geniculate, right ventral lateral posterior, and right intermediate nuclei. Although statistical significance remained borderline after FDR correction ( Conclusion: Observed volumetric trends may provide preliminary insights into the role of specific thalamic substructures in cervical dystonia pathophysiology. Further studies in larger cohorts, supported by functional and diffusion imaging, are needed to clarify these findings.
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