ArticleDevelopmental cell2026
Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis.
Abstract read
In one paragraph
Article in Developmental cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The impact of K-Ras Gly12 mutants on homeostasis and tumorigenesis in the colonic epithelium.Oncogene · 2026Article
- Prognostic Implications of Codon-SpecificJCO precision oncology · 2026Article
Corrections and comments
- Update of
Authors and funding
23 authors.
Adrien GrimontDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
David J FalvoDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Whitney J SissoDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065, USA.
Francisco SantosDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Christopher W ChanDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Paul ZumboInstitute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY 10065, USA.
William B FallDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065, USA.
Katherine FerrickDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Grace PanDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Megan ClevelandJohns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Tomer M Yaron-BarirSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065, USA.
Alexa OsterhoudtDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA.
Yinuo MengDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Weill Cornell Medicine, New York, NY 10065, USA.
Maria Paz ZafraDepartment of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Andre F RendeiroInstitute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Erika HissongDepartment of Pathology, Weill Cornell Medicine, New York, NY 10065, USA.
Rhonda K YantissDepartment of Pathology, Weill Cornell Medicine, New York, NY 10065, USA.
Doron BetelInstitute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA; Applied Bioinformatics Core, Weill Cornell Medicine, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Mark A MagnusonVanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, TN 37232, USA.
Steven D LeachJohns Hopkins University School of Medicine, Baltimore, MD 21287, USA; David M. Rubinstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Dartmouth Cancer Center, Dartmouth University, Hanover, NH 03755, USA.
Anil K RustgiHerbert Irving Comprehensive Cancer Center, Columbia University School of Medicine, New York, NY 10032, USA.
Lukas E DowSandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Rohit ChandwaniDepartment of Surgery, Weill Cornell Medicine, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA; David M. Rubinstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Cell and Developmental Biology, Weill Cornell Medicine, New York, NY 10065, USA. Electronic address: roc9045@med.cornell.edu.
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8MTranslational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3MCoordinating Center for Beta Cell Biology ConsortiumU01DK072473 · NIDDK · VANDERBILT UNIVERSITY · PI MAGNUSON, MARK A · 2005 to 2014
$61.0MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3MThe Prrx-1 transcription factor in pancreatic ductal biologyR01DK060694 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI CHANDWANI, ROHIT, RUSTGI, ANIL K · 2002 to 2025
$8.3MComprehensive genetic dissection of druggable KRAS targetsR01CA204228 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEACH, STEVEN D · 2016 to 2020
$1.9MDefining the molecular determinants of inflammatory memory in the pancreasR01DK138154 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI Rohit Chandwani · 2024 to 2026
$1.5MDefining the oncogenic potential and therapeutic dependencies of PDAC-associated KRAS variantsR01CA290616 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Rohit Chandwani, LUKAS Edward DOW · 2025 to 2026
$1.3MFunctional Proteomics by Reverse Phase Protein Array in CancerR50CA221675 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LU, YILING · 2017 to 2021
$726kUnderstanding Kras Mutation Heterogeneity in PDACF31CA288132 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Whitney Juliet Sisso · 2024 to 2026
$149kInflammation-induced cellular plasticity in pancreatic homeostasis and tumorigenesisF31CA265166 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI FALVO, DAVID · 2021 to 2023
$113kRegulation of lineage plasticity in pancreatic disease by the pioneer factor FOXA2F31DK145136 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI William Fall · 2025 to 2026
$100kNCI NIH HHS F31 CA265166NCI NIH HHS F31 CA288132NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA023108NCI NIH HHS R01 CA204228NCI NIH HHS R01 CA290616NCI NIH HHS R50 CA221675NIDDK NIH HHS F31 DK145136NIDDK NIH HHS P30 DK020593NIDDK NIH HHS R01 DK060694NIDDK NIH HHS R01 DK138154NIDDK NIH HHS U01 DK072473
Abstract
Inflammation in the pancreas drives acinar-to-ductal metaplasia (ADM), a progenitor-like state that can be hijacked by mutant Kras in the formation of pancreatic ductal adenocarcinoma. How these cell fate decisions vary according to KRAS mutation remains poorly understood. To define mutation-specific lineage reversion and tumor initiation, we implement Ptf1a-tdTomato mice and multiple KRAS mutants across several genetic, pharmacologic, and inflammatory perturbations in vivo. Whereas KRAS
Indexed as
CarcinogenesisCarcinoma, Pancreatic DuctalMutationPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)AnimalsCell LineageCell Transformation, NeoplasticHumansMetaplasiaMicePhenotypeProto-Oncogene Proteins c-aktSignal TransductionHras protein, mouseProto-Oncogene Proteins c-aktProto-Oncogene Proteins p21(ras)acinar-ductal metaplasiaEGFRepigenetic reprogrammingG12RinflammationKRASlineage reversionpancreatic ductal adenocarcinomaRAC1VAV1
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.