Evidence map›Paper›PMID 42480284›Full record

GuidelineThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

Brazilian guidelines for the diagnosis and treatment of candidemia and invasive candidiasis in adults and children.

Arnaldo L Colombo, Marcello M C Magri, Fabianne Carlesse, Diego R Falci, Marcia Garnica, Daniel W C L Santos, Flavio Queiroz-Telles, Alessandro C Pasqualotto

Abstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Candidemia and invasive candidiasis in children and neonates: transposing adult diagnostic recommendations may undermine end-organ screening.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Arnaldo L ColomboUniversidade Federal de São Paulo (UNIFESP), Instituto de Resistência Antimicrobiana de São Paulo (ARIES), São Paulo, SP, Brazil; Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil; The Latin American Center for Medical Mycology ‒ CMM LATAM, Brazil. Electronic address: arnaldo.colombo@unifesp.br.
Marcello M C MagriUniversidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Divisão de Clínica de Moléstias Infecciosas e Parasitárias, São Paulo, SP, Brazil; Centro Universitário Faculdade de Medicina do ABC (FMABC), Disciplina de Infectologia, Santo André, SP, Brasil.
Fabianne CarlesseUniversidade Federal de São Paulo (UNIFESP), Instituto de Resistência Antimicrobiana de São Paulo (ARIES), São Paulo, SP, Brazil; Grupo de Apoio ao Adolescente e Criança com Câncer (GRAACC), Instituto de Oncologia Pediátrica, São Paulo, SP, Brazil.
Diego R FalciHospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil; Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Marcia GarnicaUniversidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Daniel W C L SantosIDOR ‒ Instituto D'Or de Pesquisa e Ensino, Rede D'Or, São Luís, MA, Brazil; Hospital Universitário da Universidade Federal do Maranhão, São Luís, MA, Brazil.
Flavio Queiroz-TellesUniversidade Federal do Parana, Departamento de Saúde Pública, Curitiba, Brazil.
Alessandro C PasqualottoUniversidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil; Santa Casa de Porto Alegre, Porto Alegre, RS, Brazil; University of Minnesota, Minneapolis, MN, USA. Electronic address: pasqualotto@santacasa.org.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInvasive candidiasis, including candidemia and deep-seated Candida infections, remains a major cause of morbidity and mortality in hospitalized patients worldwide, particularly in low- and middle-income countries. In Brazil, candidemia is associated with persistently high mortality rates, driven by late diagnosis, limited access to antifungal agents, and heterogeneous diagnostic capacity. The last national guideline issued by the Brazilian Society of Infectious Diseases (SBI) was published in 2013, and substantial advances have occurred since then in epidemiology, diagnostics, and antifungal therapy.

objectivesTo provide an updated, evidence-based Brazilian guideline for the diagnosis and treatment of candidemia and invasive candidiasis in adults and children, incorporating contemporary scientific data and addressing the specific epidemiological, diagnostic, and therapeutic realities of Brazil.

methodsThis guideline was developed by the SBI Mycology Committee through a structured consensus process. Clinical questions were formulated using the PICO framework, followed by systematic literature searches of PubMed-indexed studies and international guidelines. Recommendations were contextualized according to Brazilian epidemiology, laboratory infrastructure, and access to antifungal therapies.

resultsKey updates include revised epidemiological data from Brazilian cohorts, updated recommendations for blood culture strategies and non-culture-based diagnostics, refined indications for echocardiography and fundoscopy, and updated therapeutic algorithms. Novel antifungal agents, including long acting echinocandins such as rezafungin, are discussed. Emphasis is placed on early echinocandin therapy, timely source control, antifungal stewardship, and infectious diseases consultation.

conclusionsThis updated Brazilian guideline reflects current scientific evidence while addressing national healthcare realities, aiming to standardize care, improve outcomes, and reduce mortality associated with invasive candidiasis in Brazil.

Indexed as

Antifungal AgentsCandidemiaCandidiasis, InvasiveAdultBrazilChildHumansAntifungal AgentsAntifungal therapyBrazilCandidemiaClinical guidelinesEchinocandinsInvasive candidiasis

Identifiers

PMID42480284
PMCPMC13393635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.