Evidence map›Paper›PMID 42480054›Full record

ArticleMolecular nutrition & food research2026

Effects of Low Methionine Intake on Gastric Ulcer in Patients and Mice: Role of the NNMT Pathway.

Saiying Meng, Fuhao Chen, Jiahao Chen, Yangzhuo Lin, Rui Chen, Qingmin Yan, Qihan Qin, Run Yu, Ping Jiang, Guoqing Wu

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Article in Molecular nutrition & food research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Saiying MengSchool of Public Health, Health Science Center, Ningbo University, Ningbo, P. R. China.
Fuhao ChenSchool of Public Health, Health Science Center, Ningbo University, Ningbo, P. R. China.
Jiahao ChenDepartment of Prevention, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, P. R. China.
Yangzhuo LinSchool of Public Health, Health Science Center, Ningbo University, Ningbo, P. R. China.
Rui ChenSchool of Public Health, Health Science Center, Ningbo University, Ningbo, P. R. China.
Qingmin YanSchool of Public Health, Health Science Center, Ningbo University, Ningbo, P. R. China.
Qihan QinSchool of Public Health, Health Science Center, Ningbo University, Ningbo, P. R. China.
Run YuSchool of Public Health, Health Science Center, Ningbo University, Ningbo, P. R. China.
Ping JiangSchool of Public Health, Health Science Center, Ningbo University, Ningbo, P. R. China.
Guoqing WuSchool of Public Health, Health Science Center, Ningbo University, Ningbo, P. R. China.

Funding

High-Level Scientific and Technological Research Project of Ningbo University GJPY2026046National Natural Science Foundation of China 82103836the Natural Science Foundation of Zhejiang Province LQ22H260002
6 · The paper itself

Abstract

Excessive methionine intake exacerbates gastrointestinal toxicity in mice. Conversely, dietary methionine restriction (MR) suppressed the invasiveness and spread of gastric cancer cells. However, its effects on gastric ulcers (GU) remain unclear. This study aimed to reveal the relationship between methionine intake and GU risk and the role and regulatory mechanism of MR in mice with GU. Logistic regression analysis of the population data showed a significant positive correlation between higher methionine intake and elevated GU risk in adults aged 18-50 years (OR = 1.016, 95% Confidence Interval (CI): 1.005-1.028, p = 0.024). Patients showed notably higher methionine intake levels than healthy controls. GU model mice (Male C57BL/6 mice, 11 weeks old, n = 6/group) treated with MR exhibited significant alleviation of gastric bleeding, edema, and inflammation, a reduction in the ulcer index, and 62.65% inhibition of GU. Furthermore, based on the unique metabolic pathway of methionine, this study demonstrated that MR inhibited gastric nicotinamide N-methyltransferase (NNMT) expression and elevated the NAD

Indexed as

MethionineNicotinamide N-MethyltransferaseStomach UlcerAdolescentAdultAnimalsFemaleHumansInterleukin-1betaMaleMiceMice, Inbred C57BLMiddle AgedYoung AdultInterleukin-1betaMethionineNicotinamide N-Methyltransferasegastric ulcermethionine intakemethionine restrictionnicotinamide N‐methyltransferase

Identifiers

PMID42480054
PMCPMC13387750

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.