ArticleRapid communications in mass spectrometry : RCM2026
LC-MS/MS-Based Phytochemical Characterization of Cakile maritima Methanol Extract and Its Photodynamic Anticancer Activity in Gastric Cancer Cells.
Article in Rapid communications in mass spectrometry : RCM, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
rationaleIn this study, the phytochemical composition, in vitro anticancer activity, photodynamic therapy (PDT) activity, and molecular interaction potential with carbonic anhydrase IX (CA IX) of Cakile maritima methanol extract were evaluated. METHODS AND
resultsLC-MS/MS analysis identified 11 compounds among 35 screened phytochemicals, with fumaric acid (13797.19 ppb), ferulic acid (771.37 ppb) and p-coumaric acid (601.95 ppb) accounting for approximately 97% of the total content. Molecular docking results demonstrated that sinapic acid (-6.13 kcal/mol) and quinic acid (-6.11 kcal/mol) exhibited the highest binding affinities toward CA IX. Cell culture studies revealed that LogIC
conclusionsThese findings indicate that C. maritima methanol extract exhibits light-enhanced cytotoxicity in MKN-28 gastric cancer cells and warrant further investigation regarding its potential photosensitising properties.
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