Evidence map›Paper›PMID 42479833›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Single-cell atlas of the mouse ovary reveals molecular drivers of aging and senescence during the estropausal transition.

Xifan Wang, Jiping Yang, Chen Jin, Xizhe Wang, Daniela Contreras, Melody Devos, Maggie M Kane, Michael G Rosenfeld, Yousin Suh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xifan Wang *Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032.ORCID 0009-0008-9979-9014
Jiping Yang *Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032.
Chen JinDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032.
Xizhe WangDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032.
Daniela ContrerasDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032.
Melody DevosDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032.
Maggie M KaneDepartment of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032.
Michael G RosenfeldDepartment of Medicine, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0002-1572-156X
Yousin SuhDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032.

Funding

THE IMPACT OF CELLULAR DEFENSE ON THE ROLE OF Ku80 IN GENOME MAINTENANCE AND LONGP01AG017242 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI VIJG, JAN · 1999 to 2023
$46.1M
Combinatorial Actions of Genetic Variants and Gender Bias of Alzherimer's DiseaseR01AG057706 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GAGE, FRED H, GLASS, CHRISTOPHER K · 2017 to 2021
$8.1M
Resilience to Alzheimer's disease in humans with exceptional longevityR01AG057909 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BARZILAI, NIR J, ZHANG, ZHENGDONG · 2017 to 2021
$6.2M
Enhancer-based Immune and Beta Cell Dysregulation Underlying T1D RiskR01DK127778 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI EGLI, DIETER MEINRAD, ROSENFELD, MICHAEL G · 2020 to 2023
$4.5M
Systems Modeling of Alzheimers Disease in C. elegansRF1AG057341 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MURPHY, COLEEN TARA, SUH, YOUSIN · 2017 to 2017
$3.7M
Molecular Mechanisms and Genetic Basis of Human Ovarian AgingRF1AG093116 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MICHAEL G ROSENFELD, YOUSIN SUH · 2025 to 2026
$3.6M
A stress-induced promoter pause release program in cardiomyocytes protecting against myocardial infarctionR01HL150521 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G · 2020 to 2023
$2.7M
Human tissue specific age-related gene expression changes, their genetic regulations and the link to human diseasesR01AG055501 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI TU, ZHIDONG · 2018 to 2022
$2.2M
From in vivo to in vitro heterochronic parabiosis to identify geronic factorsR01AG057433 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RANDO, THOMAS A., SUH, YOUSIN · 2017 to 2020
$2.1M
The Aging vs Disease Trajectory Trees of CNS Cell Types Based on Simultaneous Single Nuclear Global Genomic AnalysesR01AG061521 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROSENFELD, MICHAEL G, SUH, YOUSIN · 2019 to 2021
$2.1M
Regulatory Landscape of the Aging Human OvaryR01AG069750 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ROSENFELD, MICHAEL G, SUH, YOUSIN · 2020 to 2024
$1.7M
Glenn Foundation for Medical Research (GFMR) PD25221Global Consortium for Reproductive Longevity GCRLE-1320HHS | NIH (NIH) AG069750HHS | NIH (NIH) DK127778 AG057433 AG061521 HL150521 AG055501 AG057341 AG057433 AG057706 AG057909 AG017242NHLBI NIH HHS R01 HL150521NIA NIH HHS P01 AG017242NIA NIH HHS R01 AG055501NIA NIH HHS R01 AG057433NIA NIH HHS R01 AG057706NIA NIH HHS R01 AG057909NIA NIH HHS R01 AG061521NIA NIH HHS R01 AG069750NIA NIH HHS RF1 AG057341NIA NIH HHS RF1 AG093116NIDDK NIH HHS R01 DK127778Simons Foundation (SF) N/A
6 · The paper itself

Abstract

Reproductive aging in mice leads to estropause, characterized by estrous cycle irregularity and eventual cessation, yet its underlying mechanism remains unclear. Here, we present a comprehensive single-cell atlas of mouse ovaries across precisely defined reproductive stages-from young (regular cycling) through the estropausal transition (regular vs. irregular cycling) to post-estropause (acyclic)-and of ovary-specific senescent cells defined by high senescence-associated β-galactosidase activity. We mapped transcriptomic dynamics of ovarian aging and characterized the molecular features of ovarian senescent cells. Our analyses revealed that during the estropausal transition, irregularly cycling ovaries exhibited accelerated aging and cellular senescence features compared with regularly cycling counterparts, including increased transcriptional noise, altered conserved aging pathways such as oxidative phosphorylation and proteostasis, hormone dysregulation in granulosa cells, and elevated expression of the senescence marker

Indexed as

AgingCellular SenescenceEstrous CycleOvaryAnimalsFemaleGranulosa CellsMiceSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisTranscriptomeagingcellular senescenceestropausal transitionovarysingle-cell RNA-seq

Identifiers

PMID42479833
PMCPMC13416851

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.