ArticlePloS one2026
Maternal alcohol exposure and atopic dermatitis in offspring: A scoping review protocol.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal alcohol use is a modifiable, yet significant public health concern, causing fetal alcohol syndrome and neurodevelopmental disorders. Research has predominantly focused on the neurodevelopmental consequences of maternal alcohol consumption, but growing evidence suggests that these effects may extend to the developing immune system, potentially increasing the risk of allergic and inflammatory conditions such as atopic dermatitis in offspring, which remains underexplored. This scoping review aims to map the available literature on the association between maternal alcohol exposure (preconception and pregnancy) and atopic dermatitis in offspring, including exposure patterns, outcome measures, and hypothesized biological mechanisms. The protocol follows Joanna Briggs Institute methodology with PEO framework (Population: offspring, Exposure: maternal alcohol use, Outcome: atopic dermatitis), and has been registered prospectively on the Open Science Framework (DOI: 10.17605/OSF.IO/EWGPB). A comprehensive search of electronic databases (PubMed, Scopus, Embase, CINAHL, Web of Science) and grey literature sources will be conducted from inception through the final search date. Two independent reviewers will screen titles, abstracts and full texts, with disagreements resolved by consensus or third-reviewer arbitration. Peer-reviewed original research articles in English reporting maternal alcohol use and diagnosed atopic dermatitis in offspring will be included. Data extraction will comprise study characteristics, exposure timing and measurement, outcome diagnostic criteria and age of assessment, key findings, and reported biological mechanisms. The preliminary findings will be validated through consultation with clinical stakeholders, including experts in allergy medicine, paediatricians, dermatologists, psychiatrists and obstetricians, to maximise the review's relevance and to identify practical implications for antenatal care and paediatric dermatology. Results will be presented through narrative synthesis, following PRISMA-ScR guidelines, to identify evidence gaps and inform future research and policy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.