ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2026
Antibacterial photoswitchable triazenic ciprofloxacins.
Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Antibiotics can be released into the environment when used to treat bacterial infections in humans and animals. These residues are poorly removed by wastewater treatment processes, leading to the selection of bacterial antibiotic resistance that impacts human, animal, and environmental health. To combat antibiotic resistance, photopharmacology is a promising emerging technology. Based on the coupling of an antibiotic with a photochromic unit, it enables the spatiotemporal control of the drug's antibacterial activity by modulating the conformation of the molecules using light. Couplings between ciprofloxacin and photochromic nuclei have led to the synthesis of the Triazole-Ciprofloxacin (TC) compound families. The antibacterial activity of the compounds was evaluated through an initial screening at a concentration of 50 mg/L in the absence and presence of UV
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