ArticleMolecular biology reports2026
The role of STRA6 induced by ONECUT2 drives malignant progression and radioresistance in rectal cancer through activating the Wnt/β-Catenin signaling pathway.
Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundStimulated by retinoic acid 6 (STRA6) is widely recognized for its roles in the pathogenesis and progression of multiple cancers. However, its biological functions and molecular mechanisms in rectal cancer (RC) remain poorly understood. This study aims to elucidate the functional roles of STRA6 and investigate the mechanisms underlying its dysregulation in RC.
methodsWe employed RNA-seq to identify differentially expressed genes. STRA6 expression levels and activation of the Wnt/β-catenin pathway in RC were assessed using reverse transcription-quantitative PCR and Western blotting. Functional implications of these genes were investigated through a series of assays, such as CCK-8, flow cytometry and transwell assays. Potential upstream transcription factors regulating STRA6 were predicted bioinformatically and validated using a dual-luciferase reporter assay. Finally, the in vivo relevance of these findings was evaluated in a xenograft mouse model.
resultsA marked increase in STRA6 and One cut domain family member 2 (ONECUT2) expression was observed in RC tissues, with particularly elevated levels detected in radiation -resistant RC tissues. Functionally, STRA6 overexpression enhanced RC cell proliferation, migration and invasion, while reducing apoptosis. Rescue experiments demonstrated that the oncogenic effects of ONECUT2 were partially reversed upon STRA6 knockdown. Mechanistically, ONECUT2 was identified as a transcription factor that binds directly to the STRA6 promoter and upregulates its expression, thereby activating the Wnt/β-catenin pathway to facilitate RC progression and radiation resistance.
conclusionONECUT2/STRA6 axis exerts an oncogenic function in RC through activation of Wnt/β-catenin pathway, suggesting its potential as a therapeutic target. NOVELTY AND IMPACT: STRA6 is widely recognized for its roles in the pathogenesis and progression of multiple cancers. but its role in rectal cancer (RC) remains unclear. This study clarified STRA6's function in RC and identified ONECUT2 as its upstream transcription factor regulating the Wnt/β-catenin pathway to facilitate RC progression and radiation resistance. The findings provide novel insights into the prognostic and functional role of STRA6 in RC and underscore its potential as a promising therapeutic target.
Indexed as
Identifiers
42479311What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.