Evidence map›Paper›PMID 42479281›Full record

ArticleHead and neck pathology2026

Malignant Odontogenic Tumors: A Clinicopathological Study of 53 Cases in Brazil.

Lorena Paula de Paula, Flávia Sirotheau Correa Pontes, Felipe Paiva Fonseca, Pablo Agustin Vargas, Marcio Ajudarte Lopes, Alan Roger Dos Santos Silva, Jacks Jorge Júnior, Paulo Victor Mendes Penafort, Adalberto Mosqueda-Taylor, Paulo Sérgio da Silva Santos and 16 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Lorena Paula de PaulaOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil. lorenna.paula@hotmail.com.ORCID http://orcid.org/0009-0004-8154-1702
Flávia Sirotheau Correa PontesService of Oral Pathology, João de Barros, Barreto University Hospital, Federal University of Pará, Belém, Pará, Brazil.ORCID http://orcid.org/0000-0003-3042-2880
Felipe Paiva FonsecaDepartment of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.ORCID http://orcid.org/0000-0002-6657-4547
Pablo Agustin VargasOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-1840-4911
Marcio Ajudarte LopesOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-6677-0065
Alan Roger Dos Santos SilvaOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-2040-6617
Jacks Jorge JúniorOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-8808-8104
Paulo Victor Mendes PenafortOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-7032-5762
Adalberto Mosqueda-TaylorHealth Care Department, Universidad Autónoma Metropolitana, Mexico City, Mexico.ORCID http://orcid.org/0000-0001-8956-6016
Paulo Sérgio da Silva SantosBauru School of Dentistry of University of São Paulo, Bauru, SP, Brazil.ORCID http://orcid.org/0000-0002-0674-3759
Vanessa Soares LaraBauru School of Dentistry of University of São Paulo, Bauru, SP, Brazil.ORCID http://orcid.org/0000-0003-1986-0003
Cléverson Teixeira SoaresLauro de Souza Lima Institute, Bauru, SP, Brazil.ORCID http://orcid.org/0000-0002-1286-5410
Décio Dos Santos Pinto JúniorDepartment of Stomatology, University of São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0001-6198-5155
Ramon RibeiroDepartment of Stomatology, University of São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-8486-4644
Elismauro Francisco de MendonçaDepartment of Stomatologic Sciences, School of Dentistry, Federal University of Goiás, Goiânia, Brazil.ORCID http://orcid.org/0000-0002-6751-3279
Diego Antônio Costa ArantesDepartment of Stomatologic Sciences, School of Dentistry, Federal University of Goiás, Goiânia, Brazil.ORCID http://orcid.org/0000-0002-1306-747X
Eneida Franco VencioDepartment of Stomatologic Sciences, School of Dentistry, Federal University of Goiás, Goiânia, Brazil.ORCID http://orcid.org/0000-0001-7381-4820
Izadora Fernanda Veiga de Jesus CostaDepartment of Oral Pathology, School of Dentistry, Federal University of Bahia, Salvador, Brazil.ORCID http://orcid.org/0009-0002-1816-7311
Flávia Caló de Aquino XavierDepartment of Oral Pathology, School of Dentistry, Federal University of Bahia, Salvador, Brazil.ORCID http://orcid.org/0000-0002-0199-6503
Jean Nunes Dos SantosDepartment of Oral Pathology, School of Dentistry, Federal University of Bahia, Salvador, Brazil.ORCID http://orcid.org/0000-0001-7225-5879
Rogério GondakDepartment of Pathology, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.ORCID http://orcid.org/0000-0001-7547-660X
Filipe Modolo SiqueiraDepartment of Pathology, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.ORCID http://orcid.org/0000-0002-5395-0486
Juliana Lucena SchusselDepartment of Stomatology, Federal University of Paraná, Curitiba, PR, Brazil.ORCID http://orcid.org/0000-0001-5204-0782
Heliton Gustavo de LimaDepartment of Stomatology, Federal University of Paraná, Curitiba, PR, Brazil.ORCID http://orcid.org/0000-0002-2384-5554
Ciro Dantas SoaresOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-6861-6640
Hélder Antônio Rebelo PontesOral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-7609-8804

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to investigate the clinicopathological features of malignant odontogenic tumors (MOTs) and to provide a comprehensive characterization that enhances the current understanding of this disease group.

methodsMOTs were retrieved from six Brazilian oral pathology services between 2007 and 2025. Demographic, clinical and radiographic data were collected from the charts, and the histological H&E-stained sections were revised by two blinded pathologists; previously available immunohistochemical and molecular findings were retrieved and reviewed in selected cases and the diagnosis was established according to the 2022 World Health Organization classification.

resultsA total of 53 malignant odontogenic tumors were identified, predominantly affecting the mandible (83%), with a slight male predominance (male-to-female ratio, 1.12:1) and a mean age of 41.4 years. Ameloblastic carcinoma was the most frequent subtype (58.5%), followed by clear cell odontogenic carcinoma (18.9%), ameloblastic fibrosarcoma (13.2%), primary intraosseous carcinoma (7.5%), and ghost cell odontogenic carcinoma (1.9%).

conclusionsThis multicenter review summarizes the main features of malignant odontogenic tumors. Although rare, these tumors often exhibit locally aggressive behavior, highlighting the need for early diagnosis, accurate histopathological evaluation, and standardized reporting with long-term follow-up.

Indexed as

Jaw NeoplasmsOdontogenic TumorsAdolescentAdultAgedAged, 80 and overBrazilChildFemaleHumansMaleMiddle AgedYoung AdultAmeloblastic carcinomaMalignant odontogenic tumorOdontogenic carcinomaOdontogenic tumors

Identifiers

PMID42479281
PMCPMC13388572

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.