ArticleArchives of microbiology2026
Comparative mitochondrial genomics of Ophiocordycipitaceae fungi reveals AT bias and site-specific positive selection in the nad4 gene.
Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The fungal family Ophiocordycipitaceae (Hypocreales, Ascomycota) includes the medicinally important Ophiocordyceps sinensis. However, comparative mitogenomic analyses remain limited. Here, we analyzed mitochondrial genomes from 18 species spanning Ophiocordyceps, Cordyceps sensu stricto, Beauveria, Tolypocladium, and three outgroups, using maximum-likelihood phylogenetics (GTR + F + R3, 1000 ultrafast bootstraps), codon-usage analysis, and site-specific selection pressure estimation. Genome sizes ranged 20.7-272.5 kb (~ 13-fold), with low GC content (mean GC = 27.7%). Codon usage showed moderate-to-strong bias (ENC = 30.0-35.5), with neutrality plots supporting AT mutation pressure as the dominant force. Site-specific dN/dS analysis revealed heterogeneous selection: cob had the strongest purifying selection (mean ω = 0.80), while nad4 showed the highest mean ω (2.40). Two positively selected sites in nad4 were identified (Site 245: ω = 6.79, P = 0.045; Site 384: ω = 7.21, P = 0.036), confirmed by pairwise Nei-Gojobori analysis (mean ω = 1.70; 80.8% of comparisons ω > 1) and sliding window tests. PAML codeml M7/M8 LRT validated significant positive selection (2ΔlnL = 14.88, P = 0.00058), with BEB identifying the same two sites (posterior probability > 0.95). These results advance our understanding of mitochondrial evolution in entomopathogenic fungi and provide candidate sites for functional validation.
Indexed as
Identifiers
42479271What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.