Evidence map›Paper›PMID 42479225›Full record

ArticleFunctional & integrative genomics2026

Development and validation of a stromal myeloid-fibrotic index and a tumor-intrinsic immune evasion index for molecular stratification in colorectal cancer.

Ismahane Abdelaziz, Badr-Eddine Allal, Bahia Djerdjouri, Abdelkader Bounaama

Abstract read
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Article in Functional & integrative genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ismahane AbdelazizTamayouz_Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene, Algiers, Algeria.
Badr-Eddine AllalTamayouz_Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene, Algiers, Algeria.
Bahia DjerdjouriTamayouz_Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene, Algiers, Algeria.
Abdelkader BounaamaTamayouz_Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Sciences and Technology Houari Boumediene, Algiers, Algeria. abdelkader.bounaama__fsb@usthb.edu.dz.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune checkpoint blockade has limited efficacy in microsatellite-stable colorectal cancer, where immune resistance may reflect stromal remodeling, tumor-intrinsic immune evasion, or both. Bulk classifications such as the Consensus Molecular Subtypes can mix these mechanisms into discrete labels. We developed two continuous indices computable from bulk data, a stromal myeloid fibrotic index (SMI) based on TGFβ signaling and an SPP1

Indexed as

Colorectal NeoplasmsTumor EscapeFibrosisHumansMacrophagesStromal CellsTumor MicroenvironmentAntigen presentationColorectal cancerImmune evasionspatial transcriptomicsStromal remodeling

Identifiers

PMID42479225

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.