Evidence map›Paper›PMID 42479090›Full record

ArticleBiomechanics and modeling in mechanobiology2026

A hybrid phenomenological finite element model of transcatheter aortic valve leaflet behaviour under non-circular annular deployment: in vitro validation and biomechanical insights.

David Agudo, Pablo Comesaña, Sofía Suárez, Irea Lopez-Garcia, Abraham Segade, Enrique Casarejos, Cesar Veiga, Laura Busto, Victor Alfonso Jimenez-Díaz, Maximilian Kütting and 1 more

Abstract readValidation Study
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In one paragraph

Article in Biomechanics and modeling in mechanobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

David AgudoCINTECX, Department of Mechanical Engineering, Universidade de Vigo, Campus As Lagoas, Marcosende, 36310, Vigo, Galicia, Spain. david.agudo@uvigo.gal.
Pablo ComesañaNsilica Simulation Technologies, Nigrán, Galicia, Spain.
Sofía SuárezCINTECX, Department of Mechanical Engineering, Universidade de Vigo, Campus As Lagoas, Marcosende, 36310, Vigo, Galicia, Spain.
Irea Lopez-GarciaCINTECX, Department of Mechanical Engineering, Universidade de Vigo, Campus As Lagoas, Marcosende, 36310, Vigo, Galicia, Spain.
Abraham SegadeCINTECX, Department of Mechanical Engineering, Universidade de Vigo, Campus As Lagoas, Marcosende, 36310, Vigo, Galicia, Spain.
Enrique CasarejosCINTECX, Department of Mechanical Engineering, Universidade de Vigo, Campus As Lagoas, Marcosende, 36310, Vigo, Galicia, Spain.
Cesar VeigaCardiovascular Research Group, Galicia Sur Health Research Institute, Vigo, Galicia, Spain.
Laura BustoCardiovascular Research Group, Galicia Sur Health Research Institute, Vigo, Galicia, Spain.
Victor Alfonso Jimenez-DíazCardiovascular Research Group, Galicia Sur Health Research Institute, Vigo, Galicia, Spain.
Maximilian KüttingNew Valve Technology GmbH, Biosensors International, Hechingen, Baden-Wurtemberg, Germany.
Andres IñiguezCardiovascular Research Group, Galicia Sur Health Research Institute, Vigo, Galicia, Spain.

Funding

Ministerio de Ciencia, Innovación y Universidades PID2024-157737NB-I00Ministry of Science, Innovation and Universities PID2024-157737NB-I00
6 · The paper itself

Abstract

Transcatheter aortic valves (TAVs) typically operate on non-circular rings, but the impact of annular ellipticity on valve mechanics remains insufficiently quantified. In this study, we present a finite element (FE) framework of a 27 mm Allegra TAV that reproduces the complete model, including stent and pericardial skirt and leaflets. The leaflets were represented using a general shell formulation that decouples the in-plane and bending responses, leading to a hybrid shell-membrane finite element model. A linear elastic constitutive law was calibrated through inverse FE analysis based on cantilever bending experiments performed on bovine pericardium. The model was validated against in vitro pulse duplicator tests for circular and highly elliptical geometries, reproducing distinctive features such as full systolic opening and the asymmetric 'pinwheel' pattern during diastolic closure. Once validated, the model is used to investigate the impact of annular ellipticity across six annular aortic geometries. Each geometry was evaluated in two limiting orientations of the ellipse's major axis (0

Indexed as

Aortic ValveFinite Element AnalysisModels, CardiovascularTranscatheter Aortic Valve ReplacementAnimalsBiomechanical PhenomenaCattleHeart Valve ProsthesisPericardiumReproducibility of ResultsStress, MechanicalAortic annulus ellipticityFinite element analysisIn vitro validationLeaflet coaptationPericardial tissue mechanicsTranscatheter aortic valve

Identifiers

PMID42479090
PMCPMC13388641

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.