Evidence map›Paper›PMID 42479087›Full record

ArticleCancer immunology, immunotherapy : CII2026

Dual inhibition of tumor cells and tumor-associated neutrophils by anti-CXCR2 antibodies suppresses tumor growth and augments immunotherapy efficacy in ARID1A-deficient pancreatic cancer.

Tzu-Lei Kuo, Kuan-Chung Hsiao, Ko-Jiunn Liu, Li-Tzong Chen, Wen-Chun Hung

Abstract read
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tzu-Lei KuoNational Institute of Cancer Research, National Health Research Institutes, No. 367, Sheng-Li Road, Tainan, 704, Taiwan.
Kuan-Chung HsiaoNational Institute of Cancer Research, National Health Research Institutes, No. 367, Sheng-Li Road, Tainan, 704, Taiwan.
Ko-Jiunn LiuNational Institute of Cancer Research, National Health Research Institutes, No. 367, Sheng-Li Road, Tainan, 704, Taiwan.
Li-Tzong ChenNational Institute of Cancer Research, National Health Research Institutes, No. 367, Sheng-Li Road, Tainan, 704, Taiwan.
Wen-Chun HungNational Institute of Cancer Research, National Health Research Institutes, No. 367, Sheng-Li Road, Tainan, 704, Taiwan. hung1228@nhri.edu.tw.

Funding

National Science and Technology Council 110-2327-B-037 -001National Science and Technology Council 114-3111-Y-043-001
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is largely resistant to immune checkpoint blockade (ICB) due to its highly immunosuppressive tumor microenvironment. How to switch the "immune-cold" microenvironment to "immune hot" one is a clinical unmet need. We recently generated a genetically engineered PDAC mouse model (KAR) by combining K-Ras mutation and AT-rich interactive domain-containing protein 1A (ARID1A) inactivation in the pancreas. Compared to the KPC (K-Ras mutation + p53 inactivation) tumors, KAR tumors express higher C-X-C chemokine receptor 2 (CXCR2) and have more CXCR2

Indexed as

Antibodies, MonoclonalCarcinoma, Pancreatic DuctalDNA-Binding ProteinsImmunotherapyNeutrophilsPancreatic NeoplasmsReceptors, Interleukin-8BTranscription FactorsAnimalsAntineoplastic Agents, ImmunologicalCell Line, TumorCell ProliferationHumansMiceTumor MicroenvironmentAntibodies, MonoclonalAntineoplastic Agents, ImmunologicalCXCR2 protein, humanDNA-Binding ProteinsReceptors, Interleukin-8BTranscription FactorsAT-rich interactive domain-containing protein 1AC-X-C chemokine receptor 2ImmunotherapyPancreatic ductal adenocarcinoma

Identifiers

PMID42479087
PMCPMC13680342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.