Evidence map›Paper›PMID 42479073›Full record

SynthesisEuropean journal of clinical pharmacology2026

Proton pump inhibitors for prevention of upper and lower gastrointestinal bleeding in patients taking aspirin: a systematic review and meta-analysis.

Siqi Jia, Yuhang Yin, Wenhui Huo, Huiyuan Lu, Yanhong Gao, Xingshun Qi

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in European journal of clinical pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Siqi Jia *Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of the Shenyang Pharmaceutical University), No. 83 Wenhua Road, Shenyang, 110840, Liaoning Province, China.
Yuhang Yin *General Hospital of Northern Theater Command, China Medical University, Shenyang, China.
Wenhui Huo *Department of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of the Shenyang Pharmaceutical University), No. 83 Wenhua Road, Shenyang, 110840, Liaoning Province, China.
Huiyuan LuDepartment of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of the Shenyang Pharmaceutical University), No. 83 Wenhua Road, Shenyang, 110840, Liaoning Province, China.
Yanhong GaoDepartment of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of the Shenyang Pharmaceutical University), No. 83 Wenhua Road, Shenyang, 110840, Liaoning Province, China.
Xingshun QiDepartment of Gastroenterology, General Hospital of Northern Theater Command (Teaching Hospital of the Shenyang Pharmaceutical University), No. 83 Wenhua Road, Shenyang, 110840, Liaoning Province, China. xingshunqi@126.com.ORCID https://orcid.org/0000-0002-9448-6739

Funding

Independent Research Funding of the General Hospital of Northern Theater Command ZZKY2024027 and ZZKY2024018Liaoning Revitalization Talents Program XLYC2203078
6 · The paper itself

Abstract

objectivesProton pump inhibitors (PPIs) are recommended for the prevention of aspirin-associated gastrointestinal mucosal injury, but emerging evidence indicates that PPIs may increase the risk of lower gastrointestinal bleeding (LGIB). This meta-analysis aimed to comprehensively evaluate the effects of PPIs on gastrointestinal bleeding (GIB).

methodsMajor electronic databases were searched to identify the studies evaluating the differences between PPIs versus placebo/blank, no-PPI, histamine-2 receptor antagonists (H

resultsSixteen randomized controlled trials (RCTs) and 14 non-RCTs were included. PPIs group had significantly lower risk of upper gastrointestinal bleeding (UGIB) than placebo/blank group (7 RCTs, RR = 0.30, 95%CI = 0.19-0.46; 2 non-RCTs, RR = 0.05, 95%CI = 0.01-0.42), no-PPI group (7 non-RCTs, RR = 0.50, 95%CI = 0.38-0.66), H

conclusionsThe evidence from RCTs and non-RCTs suggests the advantages of PPIs over placebo/blank, no-PPI, H

Indexed as

AspirinGastrointestinal HemorrhageProton Pump InhibitorsHistamine H2 AntagonistsHumansAspirinHistamine H2 AntagonistsProton Pump InhibitorsAspirinEfficacyGastrointestinal bleedingP-CABsPPIs

Identifiers

PMID42479073

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.