Evidence map›Paper›PMID 42479048›Full record

ArticleLangenbeck's archives of surgery2026

Impairment of preoperative activities of daily living predicts poor prognosis after surgery for perihilar cholangiocarcinoma.

Takashi Ofuchi, Kosuke Mima, Hiromitsu Hayashi, Kosuke Kanemitsu, Yuki Adachi, Takuya Tajiri, Taichi Horino, Rumi Itoyama, Yuki Kitano, Hirohisa Okabe and 1 more

Abstract read
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In one paragraph

Article in Langenbeck's archives of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Takashi OfuchiDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Kosuke MimaDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Hiromitsu HayashiDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan. hhayasi@kumamoto-u.ac.jp.
Kosuke KanemitsuDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Yuki AdachiDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Takuya TajiriDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Taichi HorinoDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Rumi ItoyamaDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Yuki KitanoDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Hirohisa OkabeDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.
Masaaki IwatsukiDepartment of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposesPerihilar cholangiocarcinoma (PHC) is a rare malignancy with rising incidence and mortality. With global population aging, more patients present with impaired activities of daily living (ADL), potentially influencing surgical outcomes. This study aimed to assess the association between preoperative Barthel Index (BI) scores, a measure of ADL, and survival outcomes after PHC surgery.

methodsWe retrospectively analyzed 88 patients who underwent PHC resection from 2005 to 2020. Preoperative ADL was evaluated using the BI (range 0-100), with scores ≤ 95 defined as impaired. Cox proportional hazards regression was used to assess the impact of ADL on survival, adjusting for confounders.

resultsAmong the 88 patients, 29 (33%) had impaired preoperative ADL (BI ≤ 95). Multivariable analysis revealed that impaired ADL was independently associated with worse overall survival (HR: 1.90, 95% CI: 1.05-3.40, P = 0.031) and recurrence-free survival (HR: 2.35, 95% CI: 1.36-4.07, P = 0.002).

conclusionsImpaired preoperative ADL is linked to poor prognosis in PHC patients. Efforts to maintain or improve perioperative ADL may enhance long-term outcomes after surgery.

Indexed as

Activities of Daily LivingBile Duct NeoplasmsKlatskin TumorAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesSurvival RateFrailGeriatricsMorbidityOncologyPerihilar cholangiocarcinoma

Identifiers

PMID42479048

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.