Evidence map›Paper›PMID 42478997›Full record

ArticleJournal of obesity2026

Anthropometric and Metabolic Traits Across Ancestries in the UK Biobank.

Delnaz Roshandel, Andrew D Paterson, Satya Dash

Abstract read
In one paragraph

Article in Journal of obesity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Delnaz RoshandelDepartment of Genetics, Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada, sickkids.ca.ORCID https://orcid.org/0000-0002-4902-8587
Andrew D PatersonDepartment of Genetics, Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada, sickkids.ca.ORCID https://orcid.org/0000-0002-9169-118X
Satya DashInstitute of Medical Sciences, Department of Medicine, University of Toronto, Toronto, Ontario, Canada, utoronto.ca.ORCID https://orcid.org/0000-0002-5167-2099

Funding

CIHR PJT 450973Heart and Stroke Foundation of Canada G- -21-0031489
6 · The paper itself

Abstract

aimsIncreased waist-hip ratio (WHR) increases free fatty acid (FFA) flux, contributing to dysglycemia and dyslipidemia in Europeans. We examined these phenomena in non-Europeans, a group with higher prevalence of metabolic disease.

methodsWe undertook sex-stratified analyses of WHR, body composition, HbA1c, lipids and total FFA in people without diabetes (Males: 153,613, Females: 193,574) of European (E, N = 333,465), African (A, N = 2040), African American (AA, N = 2808), South Asian (SA, N = 5121), East Asian (EA, N = 1374), Asian-Pacific Islander (API, N = 570) and Latin American 1 (LA-1, Puerto Rican and Dominican, N = 1400) and Latin American 2 (LA-2, Mexican and Mexican American, N = 409) ancestry as defined by genetic data in the UK Biobank. Sex-matched Es were the comparator group for all analyses.

resultsAfter adjustment for WHR, socioeconomic status, smoking, alcohol use, physical activity and menopause status in females, all groups except LA-2 males had significantly higher HbA1c (p < 2E - 3). Increased FFA and dyslipidemia was only seen in EA and API males but not females. SA males and females had dyslipidemia with no increase in FFA. A and AA males and females had lower FFA and improved lipids, while no significant differences were seen in lipid parameters amongst LA-1 males and females and LA-2 females compared to Es.

conclusionsDysglycemia is seen in most non-E ancestries after adjustment for WHR and does not always associate with increased FFA and dyslipidemia. This indicates that factors beyond body composition and lipid flux may contribute to metabolic disease in non-Es.

Indexed as

AdultAfrican PeopleAgedAnthropometryBody CompositionDyslipidemiasEuropean PeopleFatty Acids, NonesterifiedFemaleGlycated HemoglobinHumansLipidsMaleMiddle AgedSouth Asian PeopleUK BiobankFatty Acids, NonesterifiedGlycated HemoglobinLipids

Identifiers

PMID42478997
PMCPMC13387133

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.