Evidence map›Paper›PMID 42478952›Full record

ArticleRadiology2026

Quantitative Susceptibility Mapping Shows Size-dependent Focused Ultrasound-mediated Therapeutic Delivery to Naive Brain and Gliomas in Mice.

Matthew R Hoch, Victoria R Breza, G Wilson Miller, Richard J Price

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Matthew R HochDepartment of Biomedical Engineering, University of Virginia, 415 Lane Rd, MR-5, Rm 2316, Charlottesville, VA 22908.ORCID 0000-0002-9721-3445
Victoria R BrezaDepartment of Biomedical Engineering, University of Virginia, 415 Lane Rd, MR-5, Rm 2316, Charlottesville, VA 22908.ORCID 0000-0003-2294-7222
G Wilson Miller *Department of Biomedical Engineering, University of Virginia, 415 Lane Rd, MR-5, Rm 2316, Charlottesville, VA 22908.ORCID 0000-0002-4833-8321
Richard J Price *Department of Biomedical Engineering, University of Virginia, 415 Lane Rd, MR-5, Rm 2316, Charlottesville, VA 22908.ORCID 0000-0002-0237-2102

Funding

Genome Editing the Blood-Brain Barrier with Sonoselective Focused UltrasoundR01EB030744 · NIBIB · UNIVERSITY OF VIRGINIA · PI PRICE, RICHARD J. · 2021 to 2024
$2.4M
Focused ultrasound pre-conditioning for augmented nanoparticle penetration in infiltrative gliomasR01EB030409 · NIBIB · UNIVERSITY OF VIRGINIA · PI HANES, JUSTIN S., PRICE, RICHARD J. · 2021 to 2024
$2.3M
Toward precision radiotherapy: Physiological modeling of respiratory motion based on ultra-quality 4D-MRIR01CA226899 · NCI · UNIVERSITY OF VIRGINIA · PI CAI, JING, MILLER, G. WILSON · 2019 to 2023
$2.2M
Small-Animal 9.4T MRI for Biomedical ResearchS10OD025024 · OD · UNIVERSITY OF VIRGINIA · PI BERR, STUART S. · 2019 to 2019
$2.0M
ImmunoPET Assessment of anti-CD47 Immunotherapy Delivery to Glioblastoma with Focused UltrasoundR21NS118278 · NINDS · UNIVERSITY OF VIRGINIA · PI PRICE, RICHARD J. · 2020 to 2020
$420k
Quantification of Focused Ultrasound-Mediated Macromolecular Delivery to Brain Tumors with MRIR21CA297838 · NCI · UNIVERSITY OF VIRGINIA · PI G. Wilson Miller, Richard J. Price · 2026 to 2026
$404k
NCI NIH HHS R01 CA226899NCI NIH HHS R21 CA297838NIBIB NIH HHS R01 EB030409NIBIB NIH HHS R01 EB030744NIH HHS S10 OD025024NINDS NIH HHS R21 NS118278
6 · The paper itself

Abstract

Background Focused ultrasound US (FUS)-mediated disruption of the blood-brain barrier (BBB) and blood-tumor barrier (BTB) augments therapeutic delivery; however, relationships between dose, agent size, and delivery to both healthy and tumor tissue with FUS remain poorly defined. Purpose To evaluate quantitative susceptibility mapping (QSM) for quantifying delivery of iron oxide nanoparticles (IONPs) after FUS-mediated BBB and BTB disruption and investigate how delivery efficiency varies with particle size in naive and glioma-bearing mice. Materials and Methods FUS-mediated BBB and BTB disruption was performed on 8-11-week-old naive (

Indexed as

Brain NeoplasmsDrug Delivery SystemsGliomaAnimalsBlood-Brain BarrierContrast MediaDisease Models, AnimalFemaleMagnetic Resonance ImagingMeglumineMiceMice, Inbred C57BLMicrobubblesOrganometallic CompoundsParticle SizeContrast Mediagadobenic acidMeglumineOrganometallic Compounds

Identifiers

PMID42478952
PMCPMC13421230

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.