Evidence map›Paper›PMID 42478837›Full record

ArticlemBio2026

Mucosal boosting of chimpanzee adenovirus-vectored vaccine encoding SARS-CoV-2 RBD-heterodimer provides robust protection in mice.

Xueyuan Liu, Yaling An, Huixin Duan, Fei Shao, Ke Xu, Chenxi Yang, Senyu Xu, Xuemei Zhou, Minrun Duan, Tianyi Zheng and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Xueyuan LiuSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China.ORCID 0009-0008-4319-0568
Yaling AnCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.
Huixin DuanCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.
Fei ShaoCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.
Ke XuNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China.
Chenxi YangCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.
Senyu XuMedical School, University of Chinese Academy of Sciences, Beijing, China.
Xuemei ZhouCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.
Minrun DuanCollege of Animal Science and Veterinary Medicine, Guangxi University, Nanning, China.
Tianyi ZhengZhejiang University School of Medicine, Hangzhou, China.
Shiyu SunCollege of Animal Science and Veterinary Medicine, Guangxi University, Nanning, China.
Mengjie YangNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China.
Kun CaiNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China.
William J LiuStrategic Pandemic Preparedness Action and Research Center (SPARC), Guangzhou National Laboratory, Guangzhou, China.
Dongming ZhouDepartment of Pathogen Biology, School of Basic Medical Sciences, Medical University, Tianjin, China.ORCID 0000-0002-5989-7591
Kun XuInstitute of Zoology, Chinese Academy of Sciences, Beijing, China.ORCID 0000-0002-9762-5001
Lianpan DaiCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.
Shuo WangCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.ORCID 0000-0002-5383-3386
Peipei LiuNHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China.ORCID 0000-0001-8374-9823
Wei MaSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China.ORCID 0000-0002-8092-3280
George F GaoCAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing, China.ORCID 0000-0002-3869-615X

Funding

Beijing Life Science Academy 2023000CA0020Bill & Melinda Gates Foundation INV-027420Bill & Melinda Gates Foundation INV-027420Chinese Academy of Sciences 2018113Chinese Academy of Sciences YSBR-010National Key R&D Program of China 2020YFA0907100National Key R&D Program of China 2021YFC2302600National Key R&D Program of China 2023YFC2307604National Natural Science Foundation of China 82202030Postdoctoral Fellowship Program of China Postdoctoral Science Foundation (CPSF) GZB20230818Young Elite Scientists Sponsorship Program by CAST 2022QNRC001
6 · The paper itself

Abstract

The major route of COVID-19 vaccination currently is via intramuscular injection. Data from clinical trials and real-world studies have demonstrated its effectiveness in preventing severe illness and death caused by SARS-CoV-2 infection. However, its protective efficacy against SARS-CoV-2 infection and transmission

Indexed as

Adenoviruses, SimianCOVID-19COVID-19 VaccinesImmunity, MucosalSARS-CoV-2Spike Glycoprotein, CoronavirusAdministration, IntranasalAnimalsAntibodies, NeutralizingAntibodies, ViralDisease Models, AnimalFemaleGenetic VectorsImmunization, SecondaryImmunologic MemoryInjections, IntramuscularAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Vaccines, Syntheticadenovirus-vectored vaccineaerosol inhalationmemory T cellsmucosal immune responses

Identifiers

PMID42478837
PMCPMC13463698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.