ArticleJournal of applied physiology (Bethesda, Md. : 1985)2026
Dose- and time-dependent physiological effects of fentanyl in adult goats.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Osverdoses (ODs) involving the synthetic opioid fentanyl annually contribute to thousands of deaths in the United States and are largely attributed to opioid-induced respiratory depression (OIRD). However, fentanyl OD negatively affect several aspects of cardiorespiratory function, including respiratory muscle rigidity and pulmonary gas exchange. Here, we tested the hypothesis that high doses of intravenous fentanyl (50-750 µg/kg) cause unique, time- and dose-dependent changes in physiologic functions and behaviors consistent with OIRD, muscle rigidity, impaired gas exchange, and acute withdrawal in a large animal model (adult female goats;
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