Evidence map›Paper›PMID 42478694›Full record

ArticleeLife2026

Reactive oxygen detoxification contributes to

Nicholas A Bates, Ronald Rodriguez, Rama Drwich, Abigail Ray, Sarah A Stanley, Bennett H Penn

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Genome and drug resistance analysis ofFrontiers in microbiology · 2026
    Article
  3. bioRxiv : the preprint server for biology · 2025
    Article
  4. Cell Death Mechanisms inPathogens (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Nicholas A BatesDepartment of Internal Medicine, University of California, Davis, Davis, United States.
Ronald RodriguezDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.
Rama DrwichDepartment of Internal Medicine, University of California, Davis, Davis, United States.
Abigail RayMicrobiology Graduate Group, University of California, Davis, Davis, United States.
Sarah A StanleyDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.ORCID https://orcid.org/0000-0002-4182-9048
Bennett H PennDepartment of Internal Medicine, University of California, Davis, Davis, United States.ORCID https://orcid.org/0000-0003-2458-5202

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI KC KENT LLOYD · 2002 to 2026
$84.9M
TRAINING IN COMPARATIVE LUNG BIOLOGY AND MEDICINET32HL007013 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI Elena Goncharova, Nicholas J. KENYON · 1985 to 2026
$10.1M
Understanding How the Ubiquitin Ligase CBL Regulates Innate Immune ResponsesR01AI144149 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PENN, BENNETT · 2019 to 2023
$2.4M
The role of nanocompartments in M. tuberculosis pathogenesisR01AI143722 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI STANLEY, SARAH A · 2019 to 2023
$1.9M
Acquisition of Covaris E220 and Sciclone G3 systems for high throughput sequencinS10OD010786 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI COMAI, LUCA · 2012 to 2012
$311k
National Heart Lung and Blood Institute HL007013National Institute of Allergy and Infectious Diseases R01AI143722National Institute of Allergy and Infectious Diseases R01AI144149NCI NIH HHS P30 CA093373NCI NIH HHS P30CA093373NHLBI NIH HHS T32 HL007013NIAID NIH HHS R01 AI143722NIAID NIH HHS R01 AI144149NIH HHS 1S10OD010786-01NIH HHS S10 OD010786Pew Charitable Trusts Pew Biomedical Scholars Fellowship
6 · The paper itself

Abstract

When a population of bacteria is exposed to a bactericidal antibiotic, most cells die rapidly. However, a subpopulation of antibiotic-tolerant cells known as 'persister cells' can survive for prolonged periods. In addition, antibiotic tolerance can be broadly induced throughout the population by stresses such as nutrient deprivation. However, the pathways required to maintain viability in this setting and how stress induces antibiotic tolerance are both poorly understood. To identify genetic determinants of antibiotic tolerance in mycobacteria, we carried out transposon insertion sequencing (Tn-Seq) screens in

Indexed as

Anti-Bacterial AgentsMicrobial ViabilityMycobacterium abscessusReactive Oxygen SpeciesDNA Transposable ElementsDrug Resistance, BacterialMutagenesis, InsertionalAnti-Bacterial AgentsDNA Transposable ElementsReactive Oxygen Speciesantibioticsinfectious diseasemicrobiologyMycobacterium abscessuspersisterstolerance

Identifiers

PMID42478694
PMCPMC13387744

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.