Evidence map›Paper›PMID 42478557›Full record

ArticleJournal of pediatric gastroenterology and nutrition2026

Exclusive enteral nutrition containing transforming growth factor-β improves intestinal barrier function in a colitis mouse model.

Kawthar Boumessid, Vickie Lacroix, Ekaterina Ovtchinnikova, Sophie Thenet, Marie Carriere, Frédérick Barreau, Emmanuel Mas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kawthar BoumessidINSERM UMR1220, INRAE, ENVT, University of Toulouse, Toulouse, France.
Vickie LacroixINSERM UMR1220, INRAE, ENVT, University of Toulouse, Toulouse, France.
Ekaterina OvtchinnikovaINSERM UMR1220, INRAE, ENVT, University of Toulouse, Toulouse, France.
Sophie ThenetUMR 938, Research Center of Saint-Antoine, Sorbonne University, INSERM, Paris, France.
Marie CarriereSyMMES, University of Grenoble, CEA, INP, CNRS, Grenoble, France.
Frédérick BarreauINSERM UMR1220, INRAE, ENVT, University of Toulouse, Toulouse, France.ORCID https://orcid.org/0000-0002-7150-9619
Emmanuel MasINSERM UMR1220, INRAE, ENVT, University of Toulouse, Toulouse, France.ORCID https://orcid.org/0000-0001-5425-7352

Funding

Direction Générale de l'offre de SoinsINSERMROTARY Club of Portet sur Garonne
6 · The paper itself

Abstract

objectivesExclusive enteral nutrition (EEN) is the first-line treatment for pediatric Crohn's disease, but its mechanisms of action remain poorly understood. Our aim was to identify the mechanisms that could explain the anti-inflammatory effects of EEN, studying the nutritional composition and transforming growth factor-β (TGF-β) effects, in a mouse model of colitis.

methodsMice were treated with dextran sulfate sodium (DSS) to induce colitis. After DSS treatment, we compared two enteral nutrition formulas, and we evaluated the effect of TGF-β itself on clinical and microscopic inflammation, and intestinal permeability, by TGF-β-supplementation, -inhibition, or -deletion. Colonic crypts from DSS and EEN mice were cultured and their cellular properties were analyzed.

resultsBoth EEN formulas improved weight recovery and disease activity index. In contrast, EEN mice treated with TGF-β formula presented faster weight recovery and decreased inflammatory parameters, with a normalized intestinal permeability, suggesting gut restitution and functionality. These functional improvements were not found in the absence of TGF-β in the formulas. Finally, organoids from colonic crypts treated with Modulen IBD® containing TGF-β showed enhanced survival and re-epithelialization capacity.

conclusionsBoth EEN formulas have anti-inflammatory properties based on their nutritional composition. However, TGF-β plays a significant role in intestinal functional restitution.

Indexed as

ColitisEnteral NutritionIntestinal Barrier FunctionTransforming Growth Factor betaAnimalsCrohn DiseaseDextran SulfateDisease Models, AnimalFemaleIntestinal MucosaMaleMiceMice, Inbred C57BLPermeabilityDextran SulfateTransforming Growth Factor betaCrohn's diseaseintestinal organoidsintestinal permeability

Identifiers

PMID42478557
PMCPMC13646034

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.