Evidence map›Paper›PMID 42478196›Full record

ArticleBioMed research international2026

Juglone Attenuates CCl₄-Induced Hepatic Injury in Mice With Associated Modulation of Oxidative Stress and Inflammasome-Related mRNA Expression.

Aamir Sohail, Raza Sufyan, Muhammad Asim, Mehroz Khan, Aleena Altaf, Muhammad Ehsan Ul Haq, Maimoona Arshad, Atif Ali Khan Khalil, Imran Ullah

Abstract read
In one paragraph

Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Aamir SohailDepartment of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan, qau.edu.pk.ORCID https://orcid.org/0000-0002-8982-4481
Raza SufyanDepartment of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan, qau.edu.pk.
Muhammad AsimDepartment of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan, qau.edu.pk.
Mehroz KhanDepartment of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan, qau.edu.pk.ORCID https://orcid.org/0009-0007-7358-435X
Aleena AltafDepartment of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan, qau.edu.pk.
Muhammad Ehsan Ul HaqDepartment of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan, qau.edu.pk.
Maimoona ArshadDepartment of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan, qau.edu.pk.
Atif Ali Khan KhalilDepartment of Biotechnology, Yeungnam University, Gyeongsan, Republic of Korea, yu.ac.kr.ORCID https://orcid.org/0000-0003-1450-5635
Imran UllahDepartment of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan, qau.edu.pk.ORCID https://orcid.org/0000-0003-4259-2844

Funding

National Research Foundation of Korea RS-2025-25416339Quaid-i-Azam University URF 2020-2021
6 · The paper itself

Abstract

Carbon tetrachloride-induced liver injury is a well-established model of toxic hepatitis, characterized by marked oxidative and inflammatory damage. It remains a relevant experimental system because broadly effective therapeutic options are still limited. Juglone, a natural naphthoquinone derived from Reynoutria japonica, has demonstrated antioxidant and anti-inflammatory potential. However, mouse evidence combining standard liver injury measures with stress- and cell-death gene profiling remains limited. Building on juglone studies in injury and fibrosis, we tested juglone in a CCl

Indexed as

Chemical and Drug Induced Liver InjuryInflammasomesNaphthoquinonesOxidative StressAnimalsApoptosisCarbon TetrachlorideGene Expression RegulationLiverMaleMiceMice, Inbred C57BLRNA, MessengerCarbon TetrachlorideInflammasomesjugloneNaphthoquinonesRNA, Messengercarbon tetrachloride (CCl₄)fibrosisjugloneliver injuryNLRP3 inflammasomepyroptosis

Identifiers

PMID42478196
PMCPMC13386151

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.