Evidence map›Paper›PMID 42478179›Full record

ArticleFuture science OA2026

Ozone therapy by rectal insufflation in long COVID syndrome: a preliminary study with thermographic evaluation and quality of life measurement.

Raquel Sacristan Perez, Maria José Martínez Vivas, Silvia Menéndez-Cepero, Alessio Cabizosu, Francisco-Javier Hidalgo Tallón

Abstract read
In one paragraph

Article in Future science OA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Raquel Sacristan PerezTHERMHESC Group, Chair Ribera Hospital of Molina. San Antonio Catholic University of Murcia (UCAM), Murcia, Spain.ORCID 0009-0004-8899-1175
Maria José Martínez VivasOzone Therapy and Chronic Pain, San Antonio Catholic University of Murcia (UCAM), Murcia, Spain.
Silvia Menéndez-CeperoNational Centre for Scientific Research (Retired), Havana, Cuba.
Alessio CabizosuTHERMHESC Group, Chair Ribera Hospital of Molina. San Antonio Catholic University of Murcia (UCAM), Murcia, Spain.ORCID 0000-0001-7594-2084
Francisco-Javier Hidalgo TallónOzone Therapy and Chronic Pain, San Antonio Catholic University of Murcia (UCAM), Murcia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPost-acute coronavirus disease 2019 syndrome (PACS) is a multisystemic clinical condition that clinically starting weeks or even months after acute SARS-CoV-2 (COVID 19) infections. The objective of this study was to explore change in quality of life, mechanical force and metabolic activity after ozone therapy treatment.

methodsA preliminary clinical open label study was carried out. Twenty-three patients diagnosed with PACS more than 5 months ago participated in the study. Thermography, Handgrip test and Quality of life scale SF12 were used to analyze the effects of ozone therapy on these patients.

resultsRelated to the Handgrip test, a significant improvement was recorded in T0-T1 time interval (

conclusionOur results confirmed that clinical ozone could be a potentially useful drug in improving the strength, quality of life and basal metabolism in patients with long COVID. However, we believe that further studies and larger sample sizes are needed to corroborate and support the results obtained in this preliminary trial.

Indexed as

HandgripLong covidOzoneQuality of lifeThermography

Identifiers

PMID42478179
PMCPMC13390503

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.