Evidence map›Paper›PMID 42478147›Full record

ArticleActa physiologica (Oxford, England)2026

Disruption of Claudin-2 and Trpv6 Results in Hypocalcemia, Hypercalciuria, and Altered Bone Microarchitecture in Mice.

Harneet Kaur Bhullar, Amanda Lima Deluque, Debbie D O'Neil, Wanling Pan, Michael R Doschak, Henrik Dimke, R Todd Alexander

Abstract read
In one paragraph

Article in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Harneet Kaur BhullarDepartment of Physiology, University of Alberta, Edmonton, Alberta, Canada.
Amanda Lima DeluqueWomen's and Children's Health Institute, Edmonton, Alberta, Canada.
Debbie D O'NeilDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Wanling PanDepartment of Pediatrics, University of Alberta, Edmonton, Alberta, Canada.
Michael R DoschakFaculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
Henrik DimkeDepartment of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0002-9170-2168
R Todd AlexanderDepartment of Physiology, University of Alberta, Edmonton, Alberta, Canada.

Funding

Canada Research Chairs 233384CarlsbergfondetDanmarks Frie ForskningsfondNatural Sciences and Engineering Research Council of Canada 2020-04366Novo Nordisk FondenWomen and Children's Health Research Institute (WCHRI)
6 · The paper itself

Abstract

Transepithelial calcium absorption occurs via a transcellular or paracellular pathway. The intestinal transcellular pathway relies, at least partially, on the apical calcium channel transient receptor potential vanilloid 6 (TRPV6), whereas paracellular calcium (re)absorption occurs through tight junction proteins, including claudin-2 (CLDN2). Both CLDN2 and TRPV6 are also expressed in the kidney. CLDN2 contributes to proximal tubular calcium reabsorption, whereas the functional relevance of TRPV6 remains unclear. Cldn2

Indexed as

Bone and BonesCalcium ChannelsClaudin-2ClaudinsHypercalciuriaHypocalcemiaTRPV Cation ChannelsAnimalsBone DensityCalciumFemaleMaleMiceMice, KnockoutCalciumCalcium ChannelsClaudin-2ClaudinsCldn2 protein, mouseTrpv6 protein, mouseTRPV Cation Channelsbone mineral densitycalcium homeostasisclaudin‐2paracellular calcium pathwaytranscellular calcium pathwayTrpv6

Identifiers

PMID42478147
PMCPMC13386027

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.