Evidence map›Paper›PMID 42478111›Full record

ArticleMagnetic resonance in medicine2026

Enhanced Glioblastoma Detection Through

Abdallah Salemdawod, Dirk Mayer, Abubakr Eldirdiri, Myounghee Lee, Alexander Ksendzovsky, Graeme F Woodworth, Joshua C Rogers, Nathan E Crone, Piotr J Franaszczuk, Miroslaw Janowski and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Abdallah SalemdawodDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, Maryland, USA.
Dirk MayerDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, Maryland, USA.
Abubakr EldirdiriDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-3879-3881
Myounghee LeeInvestigational Drug Service Pharmacy, University of Maryland Medical Center, Baltimore, Maryland, USA.
Alexander KsendzovskyDepartment of Neurosurgery, University of Maryland, Baltimore, Maryland, USA.
Graeme F WoodworthDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, Maryland, USA.
Joshua C RogersDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, Maryland, USA.
Nathan E CroneDepartment of Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Piotr J FranaszczukDepartment of Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Miroslaw JanowskiDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland, Baltimore, Maryland, USA.
Anna KorzeniewskaDepartment of Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-9453-7751

Funding

Diagnostic validity and safety of high-gamma language mapping with intracranial EEGR01NS115929 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Ravindra Arya, NATHAN E CRONE · 2020 to 2026
$3.9M
Metabolic imaging of nonalcoholic fatty liver diseaseR01DK106395 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MAYER, DIRK · 2016 to 2019
$1.9M
Dynamic Metabolic Imaging of Hyperpolarized SubstratesR01EB009070 · NIBIB · UNIVERSITY OF MARYLAND BALTIMORE · PI MAYER, DIRK · 2009 to 2012
$1.6M
Hyperpolarized 13C metabolic imaging in an endovascular swine model of ischemic strokeR21NS133531 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI JANOWSKI, MIROSLAW, MAYER, DIRK · 2023 to 2024
$425k
Exploiting Altered Porphyrin Synthesis for Metabolic Imaging of GlioblastomaR21CA202694 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI KAO, JOSEPH PAO YUNG, MAYER, DIRK · 2016 to 2017
$369k
Institute for Clinical and Translational Research, University of Maryland, Baltimore: Accelerated Translational Incubator Pilot grantNCI NIH HHS R21 CA202694NIBIB NIH HHS R01 EB009070NIDDK NIH HHS R01 DK106395NIH HHS R01 EB009070NIH HHS R01 NS115929NIH HHS R21 NS133531NINDS NIH HHS R01 NS115929NINDS NIH HHS R21 NS133531
6 · The paper itself

Abstract

purposeTo develop a method for statistically significant tumor delineation. Glioblastoma (GBM) remains resistant to current therapeutic strategies and is unequivocally associated with a dismal prognosis. Hyperpolarized

methodsThe new method was applied to time-resolved hyperpolarized [1-

resultsThe new approach enabled glioblastoma delineation with the NPV of 99% and the PPV of 59% in small animals. While in the larger brain of the clinical patient, with bicarbonate taken into account, NPV and PPV obtained 95% and 92% respectively.

conclusionCombining time-points of high pyruvate and lactate signal intensities increases the statistical power of two-dimensional testing. This promising technique requires further evaluation in a larger patient cohort.

Indexed as

Brain NeoplasmsGlioblastomaMagnetic Resonance ImagingAnimalsCarbon IsotopesHumansImage Processing, Computer-AssistedLactic AcidMalePyruvic AcidRatsCarbon-13Carbon IsotopesLactic AcidPyruvic Acidglioma metabolismmagnetic resonance spectroscopic imagingmetabolite kinetics

Identifiers

PMID42478111
PMCPMC13475256

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.