ArticleTurkish journal of pharmaceutical sciences2026
Antimutagenic and Antigenotoxic Effects of
Article in Turkish journal of pharmaceutical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Materials and Methods: Ethanolic (EtOH) extract and decoction (aqueous extract) were prepared from the underground parts of Results: Total ruscogenin and neoruscogenin content was calculated as 0.71% in the plant material by HPLC analyses. Neither the ethanolic nor the aqueous extract exhibited mutagenicity, while the EtOH extract showed marked antimutagenic activity at the highest concentration in the Ames test. Likewise, no genotoxicity was observed in either of the investigated extracts in the Micronucleus and Comet assays. EtOH extract exhibited antigenotoxic activity in the micronucleus assay, whereas the aqueous extract (decoction) provided no significant protection. The comet assay revealed no antigenotoxic activity for either the EtOH extract or the decoction. Overall, the underground parts of Conclusion: The EtOH extract showed remarkable antimutagenic and antigenotoxic effects. This study constitutes the first report on the genoprotective and antimutagenic effects of
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