ArticleEuropean journal of rheumatology2025
The Role and Mechanistic Effects of Methotrexate in the Treatment of Rheumatoid Arthritis.
Article in European journal of rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Methotrexate (MTX) remains a cornerstone in the management of rheumatoid arthritis (RA). Extensive basic pharmacological research has consistently demonstrated the e cacy of MTX in treating RA, while there is still insu cient understanding about the potential mechanisms. In this review, current knowledge on the mechanisms by which MTX acts in bone erosion and synovitis is summarized, and MTX-based combination therapies are discussed. Additionally, the bone-protective and anti-in%am matory roles of adenosine receptors are described, and biomarkers associated with MTX responders in RA are explored. This review sheds new light on future research directions for RA, as well as o ers evidence-based recommendations to enhance the clinical utilization of MTX in RA treatment. Cite this article as: Teng Y, Jiang L, Yin H, Deng G. The role and mechanistic e ects of methotrexate in the treatment of rheumatoid arthritis. Eur J Rheumatol. 2025:12(4), -0086, 10.5152/ eurjrheum.2025.24086.
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Registered trials
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