Evidence map›Paper›PMID 42477860›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Relationships of CSF biomarkers to cortical atrophy in early-onset Alzheimer's disease.

Alexandra Touroutoglou, Yuta Katsumi, Jennifer Hensel, Suzanne E Schindler, Laura Ibanez, Michael Brickhouse, Ani Eloyan, Ryan Eckbo, Alexander Zaitsev, Renaud La Joie and 39 more

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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

49 authors.

Alexandra TouroutoglouDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Yuta KatsumiDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Jennifer HenselDepartment of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Suzanne E SchindlerDepartment of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
Laura IbanezDepartment of Psychiatry, Washington University in St. Louis, St. Louis, Missouri, USA.
Michael BrickhouseDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Ani EloyanDepartment of Biostatistics, Center for Biostatistics and Health Data Science Brown University, Providence, Rhode Island, USA.
Ryan EckboDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Alexander ZaitsevDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Renaud La JoieDepartment of Neurology, University of California - San Francisco, San Francisco, California, USA.
Maryanne ThangarajahDepartment of Biostatistics, Center for Biostatistics and Health Data Science Brown University, Providence, Rhode Island, USA.
Alexander TauroneDepartment of Biostatistics, Center for Biostatistics and Health Data Science Brown University, Providence, Rhode Island, USA.
Prashanthi VemuriDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Dustin B HammersDepartment of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Tatiana ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Paul AisenAlzheimer's Therapeutic Research Institute, University of Southern California, San Diego, California, USA.
Laurel BeckettDepartment of Public Health Sciences, University of California - Davis, Davis, California, USA.
Robert KoeppeDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Walter A KukullDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Arthur TogaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, Los Angeles, California, USA.
Alireza AtriBanner Sun Health Research Institute, Sun City, Arizona, USA.
David ClarkDepartment of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Gregory S DayDepartment of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
Ranjan DuaraWien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami, Florida, USA.
Neill R Graff-RadfordDepartment of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
Ian M GrantDepartment of Psychiatry and Behavioral Sciences, Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
Lawrence S HonigTaub Institute and Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.
Erik C B JohnsonDepartment of Neurology and Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA.
David T JonesDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Joseph C MasdeuNantz National Alzheimer Center, Houston Methodist and Weill Cornell Medicine, Houston, Texas, USA.
Mario F MendezDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Erik MusiekDepartment of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
Chiadi U OnyikeDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Meghan RiddleDepartment of Neurology, Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Emily RogalskiHealthy Aging & Alzheimer's Research Care Center, Department of Neurology, University of Chicago, Chicago, Illinois, USA.
Stephen SallowayDepartment of Neurology, Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Sharon ShaDepartment of Neurology & Neurological Sciences, Stanford University, Palo Alto, California, USA.
R Scott TurnerDepartment of Neurology, Georgetown University, Washington, D.C., USA.
Thomas S WingoDepartment of Neurology, UC Davis Alzheimer's Disease Research Center, University of California - Davis, Davis, California, USA.
David A WolkDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Kyle WomackDepartment of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
Maria C CarrilloMedical & Scientific Relations Division, Alzheimer's Association, Chicago, Illinois, USA.
Gil D RabinoviciDepartment of Neurology, University of California - San Francisco, San Francisco, California, USA.
Liana G ApostolovaDepartment of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Jeffrey L DageDepartment of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Bradford C DickersonDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Mark C EldaiefDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
LEADS Consortium

Funding

National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
Early Onset AD Consortium - the LEAD Study (LEADS)U01AG057195 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI APOSTOLOVA, LIANA G, CARRILLO, MARIA C · 2018 to 2023
$70.3M
National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8M
THE ROLE OF ADVANCED CAA IN ALZHEIMER'S DEMENTIAP50AG005134 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI HEDDEN, JULIUS C · 1985 to 2018
$42.1M
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI · 2019 to 2026
$33.5M
Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PHILIP L DE JAGER · 2020 to 2026
$30.1M
Research Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI Corinne Pettigrew · 2020 to 2026
$29.3M
The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI ALLAN I LEVEY · 2020 to 2026
$29.0M
Stanford Alzheimer's Disease Research CenterAdmin Supp: Developing iPSC models for AD and PDP30AG066515 · NIA · STANFORD UNIVERSITY · PI Lisa Goldman Rosas · 2020 to 2026
$29.0M
Alzheimer's Association LDRFP-21-824473Alzheimer's Association LDRFP-21-828356Alzheimer's Association LEADS GENETICS-19-639372NCRR NIH HHS S10 RR021110NCRR NIH HHS S10 RR023043NCRR NIH HHS S10 RR023401NIA NIH HHS K01 AG084820NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG062677NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066506NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066511NIA NIH HHS P30 AG066515NIA NIH HHS P30 AG072977NIA NIH HHS P30 AG072979NIA NIH HHS P30 AG072980NIA NIH HHS P50 AG005134NIA NIH HHS R01 AG085377NIA NIH HHS R21 AG073744NIA NIH HHS R56 AG057195NIA NIH HHS U01 AG057195NIA NIH HHS U24 AG021886NIA NIH HHS U24 AG072122NIBIB NIH HHS P41 EB015896NIDCD NIH HHS K23 DC016912NIDCD NIH HHS R01 DC014296NIDCD NIH HHS R21 DC019567NIH HHS K01 AG084820NIH HHS K23 DC016912NIH HHS P30 AG010133NIH HHS P30 AG062421NIH HHS P30 AG062422NIH HHS P30 AG062677NIH HHS P30 AG066444NIH HHS P30 AG066462NIH HHS P30 AG066506NIH HHS P30 AG066507NIH HHS P30 AG066511NIH HHS P30 AG066515NIH HHS P30 AG072977NIH HHS P30 AG072979NIH HHS P30 AG072980NIH HHS P41EB015896NIH HHS P50 AG005134NIH HHS R01 AG085377NIH HHS R01 DC014296NIH HHS R21 AG073744NIH HHS R21 DC019567NIH HHS S10RR021110NIH HHS S10RR023043NIH HHS S10RR023401NIH HHS U24 AG072122
6 · The paper itself

Abstract

introductionAlthough cerebrospinal fluid (CSF) biomarkers reflect neurodegeneration in Alzheimer's disease (AD), it remains unclear whether these biomarkers track neurodegeneration in early-onset Alzheimer's disease (EOAD).

methodsIn 80 EOAD patients, we examined correlations between eight CSF biomarker levels and cortical thickness decreases within the EOAD cortical atrophy signature. Significant correlations were then entered into a multiple regression analysis. We also examined contributions of EOAD atrophy and CSF biomarkers to cognitive impairment.

resultsThe levels of four CSF biomarkers correlated to EOAD signature atrophy. Stepwise regression analyses revealed that CSF neurofilament light chain (NfL) levels best predicted EOAD signature atrophy. Multiple regression showed EOAD signature atrophy combined with CSF NfL levels explained more variance in cognitive impairment than either factor alone. DISCUSSION: Within EOAD patients, CSF NfL levels relate to the magnitude of cortical atrophy, and a combination of EOAD signature atrophy and CSF NfL levels most robustly predict cognitive impairment.

Indexed as

Alzheimer DiseaseCerebral CortexAgedAmyloid beta-PeptidesAtrophyBiomarkersFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedNeurofilament ProteinsPeptide Fragmentstau ProteinsAmyloid beta-Peptidesamyloid beta-protein (1-42)Biomarkersneurofilament protein LNeurofilament ProteinsPeptide Fragmentstau Proteinsamyloid beta 42/40cerebrospinal fluid biomarkerschitinase‐3‐like proteinearly‐onset Alzheimer's diseaseEOAD signatureneurofilament light chainphosphorylated tausynaptosomal‐associated proteinvisinin‐like protein 1

Identifiers

PMID42477860
PMCPMC13385208

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