ArticleBioMed research international2026
Anti-Infective Effect of Anacardium occidentale L. Flowers Against Eskape Group Bacteria In Vitro, In Vivo, and In Silico.
Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Anti-Infective Effect of Anacardium occidentale L. Flowers Against Eskape Group Bacteria In Vitro, In Vivo, and In Silico.BioMed research international · 2026Article
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Authors and funding
10 authors.
Funding
Abstract
BACKGROUND/
objectivesThe study evaluated the in vitro antibacterial activity of the ethanolic extract of Anacardium occidentale flowers (EHAo) against ESKAPE pathogens and investigated the in vivo effects of the extract in Tenebrio molitor lethally infected with Staphylococcus aureus. In silico analyses investigated the affinity of compounds with sortase A.
methodsChemical composition was characterized by HPLC and LC-MS. Antibacterial activity was determined by minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and assays of adhesion and biofilm formation using S. aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, and clinical MRSA strains. In vivo toxicity and antimicrobial efficacy were assessed in T. molitor larvae infected with S. aureus (10
resultsEHAo contained shikimic acid, gallic acid, quercetin, isoquercetin, galloyl-glucose, digalloyl-glucose, and tetragalloylglucose isomers. The extract exhibited bactericidal activity (MIC 1.25-6.25 mg/mL), with the strongest effects against S. aureus, MRSA, and E. faecalis. EHAo inhibited adhesion and biofilm formation, except in K. pneumoniae. The extract showed low toxicity in vivo and was efficient in improving the larvae's survival following lethal infection with S. aureus. All compounds showed affinity to sortase A active site. However, digalloyl-glucose displayed the highest predicted affinity.
conclusionsEHAo reduces bacterial virulence and improves survival in S. aureus-infected larvae, an activity probably related to the bactericidal activity, inhibition of adhesion and biofilm formation, and interaction with the sortase A active site.
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