Enhanced 5-aminolevulinic acid photodynamic therapy with potassium iodide for sporotrichosis: in vitro optimization and a proof-of-concept clinical case.

Yan Cui, Ruili Chen, Jingjing Tian, Shanshan Li, Junfeng Zhou

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Article in Tropical medicine and health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Yan CuiDepartment of Dermatology and Venereology, The First Hospital of Jilin University, No. 1 Xin-Min Street, Changchun, 130021, China.

Ruili ChenDepartment of Dermatology and Venereology, The First Hospital of Jilin University, No. 1 Xin-Min Street, Changchun, 130021, China.

Jingjing TianCAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, China.

Shanshan LiDepartment of Dermatology and Venereology, The First Hospital of Jilin University, No. 1 Xin-Min Street, Changchun, 130021, China.

Junfeng ZhouDepartment of Dermatology and Venereology, The First Hospital of Jilin University, No. 1 Xin-Min Street, Changchun, 130021, China. ttxs21ct@jlu.edu.cn.

Funding

the Jilin University Medical Proof-of-Concept Project 24GNYZ35the Natural Science Foundation of Jilin Province 20220508083RC

6 · The paper itself

Abstract

backgroundSporotrichosis, a chronic fungal infection caused by pathogenic Sporothrix species, involves therapeutic challenges due to the toxicity of conventional antifungals. This study investigated the enhancement of 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) with potassium iodide (KI) through in vitro and a proof-of-concept clinical case.

methodsIn vitro testing on S. globosa conidia involved preincubation with 100 mM KI followed by ALA-PDT using 0.6 M ALA and 108 J/cm

resultsPreincubation with 100 mM KI significantly enhanced the fungicidal effect of ALA-PDT against S. globosa conidia, resulting in a substantially reduced conidial survival rate compared to either administering KI after ALA-PDT or using ALA-PDT alone. Clinically, the patient treated with KI-enhanced ALA-PDT showed complete resolution of skin lesions and no recurrence during the 1-year follow-up period.

conclusionsThis study evaluates a KI-enhanced ALA-PDT regimen in a patient with sporotrichosis, providing preliminary evidence that this approach may serve as a promising therapeutic option for patients intolerant to conventional antifungal therapy.

Indexed as

Antifungal photodynamic therapyIn vitro antifungal activityLymphocutaneous infectionPotassium iodideRefractory mycosesSporotrichosis

Identifiers

PMID42477824

DOI10.1186/s41182-026-01037-y

PMCPMC13491602

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