Evidence map›Paper›PMID 42477774›Full record

ArticleRespiratory research2026

Transcriptomic profiling of pediatric asthma by diseases state and severity.

Jihoon Kim, Jelte Kelchtermans, Frank Mentch, Fengxiang Wang, James Snyder, Yichuan Liu, Joseph Glessner, Hakon Hakonarson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jihoon KimThe Center of Applied Genomics, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Jelte KelchtermansThe Center of Applied Genomics, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Frank MentchThe Center of Applied Genomics, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Fengxiang WangThe Center of Applied Genomics, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA, 19104, USA.
James SnyderThe Center of Applied Genomics, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Yichuan LiuThe Center of Applied Genomics, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Joseph GlessnerThe Center of Applied Genomics, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Hakon HakonarsonThe Center of Applied Genomics, The Children's Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA, 19104, USA. hakonarson@chop.edu.

Funding

Studies of Rare Genetic Variation in the Isolated Population of SardiniaR01HL117626 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABECASIS, GONCALO · 2013 to 2016
$10.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
Critical Life Event supplement to 'Air pollution sensitivity in pediatric asthma'K08HL173625 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Jelte Kelchtermans · 2025 to 2026
$317k
NHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS K08 HL173625NHLBI NIH HHS K08HL173625NHLBI NIH HHS R01 HL117626NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL120393NHLBI NIH HHS X01 HL-134589NIEHS NIH HHS HHSN268201600032CNIH HHS X01 HD-107379
6 · The paper itself

Abstract

backgroundDespite the high prevalence of pediatric asthma, the molecular basis of its pathogenesis remains incompletely understood, in part due to the complex and heterogeneous nature of the disease.

methodsIn this study, we performed bulk RNA sequencing of peripheral blood mononuclear cells (PBMCs) from 183 children (114 asthma cases, 69 controls) across two independent cohorts as a minimally invasive approach to capture the gene expression changes underlying asthma status and severity.

resultsOur analysis identified robust signatures of pediatric asthma, including differential expression of a canonical asthma gene (RAB7B) and two novel genes (RPP38-DT, NCAL1), which encode long non-coding RNAs. Additionally, severity-stratified analyses revealed upregulation of several immune-related genes (CCL8, ACOD1, CXCL9, SLAMF1, EPN2) and downregulation of an uncharacterized transcript (ENSG00000288973) as asthma severity increased. Enrichment and co-expression analysis further implicate impaired type I interferon signaling in asthma disease severity.

conclusionsOur results demonstrate contributions to the pathobiology of asthma among several novel molecular candidate genes, which may support future efforts towards molecular stratification of pediatric asthma.

Indexed as

AsthmaGene Expression ProfilingSeverity of Illness IndexTranscriptomeAdolescentChildChild, PreschoolCohort StudiesFemaleHumansLeukocytes, MononuclearMalePediatric AsthmaRNA-SeqSeverity

Identifiers

PMID42477774
PMCPMC13663168

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.