Evidence map›Paper›PMID 42477740›Full record

ArticleJournal of nanobiotechnology2026

An integrative multi-omics landscape of multi-dimensional cellular stress and metabolic reprogramming in melanoma treated with targeted alpha therapy.

Jiajia Zhang, Zhiling Song, Zhengguo Chen, Xiaohui Luan, Yuying Yu, Xuhao Huang, Jie Lye, Jianguo Li, Jie Gao, Yuanyou Yang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jiajia Zhang *Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Yan-chang-zhong Road, Shanghai, 200072, China.
Zhiling Song *Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Yan-chang-zhong Road, Shanghai, 200072, China.
Zhengguo Chen *NHC Key Laboratory of Nuclear Technology Medical Transformation, Department of Nuclear Medicine, Mianyang Central Hospital, Mianyang, 621000, China.
Xiaohui LuanDepartment of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No. 301 Yan-chang-zhong Road, Shanghai, 200072, China.
Yuying YuKey Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, Chengdu, 610064, P. R. China.
Xuhao HuangDepartment of Chemistry, Graduate School of Science, The University of Osaka, Toyonaka, 560-0043, Osaka, Japan.
Jie LyeKey Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, Chengdu, 610064, P. R. China.
Jianguo LiChina Institute for Radiation Protection, Taiyuan, Shanxi, China.
Jie GaoChina Institute for Radiation Protection, Taiyuan, Shanxi, China.
Yuanyou YangKey Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, Chengdu, 610064, P. R. China.
Kazuya KabayamaDepartment of Chemistry, Graduate School of Science, The University of Osaka, Toyonaka, 560-0043, Osaka, Japan.
Koichi FukaseDepartment of Chemistry, Graduate School of Science, The University of Osaka, Toyonaka, 560-0043, Osaka, Japan.
Ning LiuKey Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, Chengdu, 610064, P. R. China.
Feize LiKey Laboratory of Radiation Physics and Technology of the Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, Chengdu, 610064, P. R. China.
Fei YuNHC Key Laboratory of Nuclear Technology Medical Transformation, Department of Nuclear Medicine, Mianyang Central Hospital, Mianyang, 621000, China. yufei_021@163.com.

Funding

National Natural Science Foundation of China 82472028National Natural Science Foundation of China 82502394NHC Key Laboratory of Nuclear Technology Medical Transformation (MIANYANG CENTRAL HOSPITAL) 2022HYX008
6 · The paper itself

Abstract

purposeThis study aimed to elucidate the biological mechanisms underlying the therapeutic effects of targeted alpha therapy (TAT) using a novel

methodsB16F10 melanoma cells and tumor-bearing mice were treated with [

results[

conclusion[

Indexed as

MelanomaMelanoma, ExperimentalStress, PhysiologicalAnimalsCell Line, TumorMetabolic ReprogrammingMetabolomicsMiceMice, Inbred C57BLMultiomicsCandidate indicatorsIntegrative multi-omicsMetabolic reprogrammingMulti-dimensional cellular stressTargeted alpha therapy

Identifiers

PMID42477740
PMCPMC13663218

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.